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Site-restricted expression of cytotactin during development of the chicken-embryo

Academic Article
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Overview

authors

  • Crossin, Kathryn
  • Hoffman, S.
  • Grumet, M.
  • Thiery, J. P.
  • Edelman, Gerald

publication date

  • May 1986

journal

  • Journal of Cell Biology  Journal

abstract

  • The sequential appearance of the extracellular matrix (ECM) protein, cytotactin, was examined during development of the chicken embryo by immunohistochemical techniques. Although cytotactin was identified as a molecule that mediates glia-neuron interactions, preliminary immunohistochemical localization of the molecule suggested that it was an ECM protein with a widespread but nonetheless more restricted distribution than either fibronectin or laminin. In the present study, it was found that cytotactin is first present in the gastrulating chicken embryo. It appears later in the basement membrane of the developing neural tube and notochord in a temporal sequence beginning in the cephalic regions and proceeding caudally. Between 2 and 3 d of development, the molecule is present at high levels in the early neural crest pathways (surrounding the neural tube and somites) but, in contrast to fibronectin and laminin, is not found in the lateral plate mesoderm or ectoderm. At later times, cytotactin is expressed extensively in the central nervous system, in lesser amounts in the peripheral nervous system, and in a number of nonneural sites, most prominently in all smooth muscles and in basement membranes of lung and kidney. Cytotactin appears in adult tissues with distributions that are similar to those seen in embryonic tissues. The findings raise the possibility that certain ECM proteins contribute to pattern formation in embryogenesis as a result of their restricted expression in a spatiotemporally regulated fashion at some sites but not at others.

subject areas

  • Age Factors
  • Animals
  • Basement Membrane
  • Cell Adhesion
  • Cell Movement
  • Chick Embryo
  • Extracellular Matrix
  • Fibronectins
  • Fluorescent Antibody Technique
  • Gastrula
  • Glycoproteins
  • Laminin
  • Morphogenesis
  • Nervous System
  • Neural Crest
  • Tenascin
  • Tissue Distribution
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Identity

International Standard Serial Number (ISSN)

  • 0021-9525

Digital Object Identifier (DOI)

  • 10.1083/jcb.102.5.1917

PubMed ID

  • 2422181
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Additional Document Info

start page

  • 1917

end page

  • 1930

volume

  • 102

issue

  • 5

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