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Localization of the human jun protooncogene to chromosome region 1p31-32

Academic Article
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Overview

authors

  • Haluska, F. G.
  • Huebner, K.
  • Isobe, M.
  • Nishimura, T.
  • Croce, C. M.
  • Vogt, Peter K.

publication date

  • April 1988

journal

  • Proceedings of the National Academy of Sciences of the United States of America  Journal

abstract

  • The oncogene jun is the putative transforming gene of avian sarcoma virus 17; jun appears to be derived from a gene of the chicken genome and has homologues in several other vertebrate species. Recent genetic and immunological data indicate that jun codes for a protein that is closely related and probably identical to the transcription factor AP-1. We have isolated a genomic DNA clone encompassing the human cellular counterpart of the gene, JUN, and used this DNA to determine the chromosomal location of the gene. A panel of DNA preparations derived from rodent-human somatic cell hybrids with defined chromosome complements was first screened with the JUN probe. This Southern blot analysis indicated that JUN is situated on the short arm of chromosome 1. In situ hybridization then assigned JUN to chromosome region 1p31-32, a chromosomal region involved in both translocations and deletions of chromosomes seen in human malignancies.

subject areas

  • Animals
  • Chromosome Mapping
  • Chromosomes, Human, Pair 1
  • DNA-Binding Proteins
  • Humans
  • Hybrid Cells
  • Mice
  • Nucleic Acid Hybridization
  • Proto-Oncogene Proteins c-jun
  • Proto-Oncogenes
  • Transcription Factors
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Identity

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.85.7.2215

PubMed ID

  • 3127828
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Additional Document Info

start page

  • 2215

end page

  • 2218

volume

  • 85

issue

  • 7

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