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The LPA receptors

Academic Article
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Overview

authors

  • Fukushima, N.
  • Chun, Jerold

publication date

  • April 2001

journal

  • Prostaglandins & Other Lipid Mediators  Journal

abstract

  • Lysophosphatidic acid (LPA) is a growth factor-like lipid that produces many cellular responses. These responses, including actin cytoskeletal rearrangements, cell proliferation and inhibition of gap junction communication, have been documented in many cell types over the last 2 decades. Both non-receptor and receptor-mediated mechanisms had been implicated to explain these responses. A clear advance in this field was the cloning and functional identification of LPA receptors, and there are currently three high-affinity members, LPA1, LPA2 and LPA3 (synonymous with orphan receptor names edg-2, edg-4 and edg-7, respectively). Here we review the gene structure, expression and functions of LPA receptors. We also discuss the in vivo roles mediated by a single LPA receptor type, based on studies of the nervous system, a major locus of LPA receptor expression.

subject areas

  • Lysophospholipids
  • Nerve Tissue
  • Nuclear Proteins
  • Receptors, Cell Surface
  • Receptors, G-Protein-Coupled
  • Receptors, Lysophosphatidic Acid
  • Signal Transduction
  • Transcription Factors
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Research

keywords

  • GPCR
  • SIP
  • SPP
  • edg
  • growth factors
  • lipid signalling
  • lysophospholipids
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Identity

International Standard Serial Number (ISSN)

  • 0090-6980

Digital Object Identifier (DOI)

  • 10.1016/s0090-6980(01)00105-8

PubMed ID

  • 11324705
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Additional Document Info

start page

  • 21

end page

  • 32

volume

  • 64

issue

  • 1-4

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