Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Coagulation studies and correlative histology during experimental hemoglobinemia in rabbits

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Spector, J. I.
  • Wilson, Curtis
  • Crosby, W. H.

publication date

  • 1974

journal

  • American Journal of Pathology  Journal

abstract

  • Evidence of disseminated intravascular coagulation (DIC) was sought in New Zealand white rabbits infused with autologous, hemolyzed whole blood. Hemoglobinemia was induced in 17 rabbits by rapid intravenous injection of frozenthawed whole blood. Three dose regimens yielded mean peak plasma hemoglobin concentrations of 325, 615 and 860 mg/100 ml respectively (range 260 to 1050 mg/100 ml). Eleven control animals were infused with autologous, nonhemolyzed whole blood in similar doses. Rabbits were killed at either 15, 60, 120 or 180 minutes following infusion and multiple organ biopsies obtained immediately post-mortem. Coagulation studies demonstrated no significant alterations in prothrombin time, partial thromboplastin time, thrombin time or fibrinogen. Fibrin degradation products were not found. Histologic examination of lung, heart, liver, spleen and kidney revealed no fibrin deposition, thrombus formation or other abnormalities. We conclude from our study that induction of brief, experimental hemoglobinemia in New Zealand white rabbits, utilizing moderately large doses of autologous, hemolyzed whole blood, does not result in the development of DIC.

subject areas

  • Animals
  • Blood Coagulation
  • Blood Coagulation Tests
  • Blood Protein Disorders
  • Blood Transfusion, Autologous
  • Disseminated Intravascular Coagulation
  • Fibrinogen
  • Hemoglobins
  • Kidney
  • Liver
  • Lung
  • Myocardium
  • Prothrombin Time
  • Rabbits
  • Spleen
  • Thrombin
  • Thromboplastin
  • Urine
scroll to property group menus

Identity

PubMed Central ID

  • PMC1910790

International Standard Serial Number (ISSN)

  • 0002-9440

PubMed ID

  • 4814901
scroll to property group menus

Additional Document Info

start page

  • 567

end page

  • 572

volume

  • 74

issue

  • 3

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support