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Activation of urinary kallikrein in patients with interstitial cystitis

Academic Article
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Overview

authors

  • Zuraw, B. L.
  • Sugimoto, S.
  • Parsons, C. L.
  • Hugli, T.
  • Lotz, Martin
  • Koziol, James

publication date

  • September 1994

journal

  • Journal of Urology  Journal

abstract

  • A potential pathophysiological role for the urinary kallikrein-kinin system is suggested by the prominent symptoms of bladder pain and urinary frequency in interstitial cystitis. Kallikrein activity in the urine of 84 patients with interstitial cystitis and 33 normal volunteers was determined by cleavage of the synthetic substrate Val-Leu-Arg-pNA. Interstitial cystitis patients had significantly higher levels of kallikrein activity than did the normal volunteers. Kallikrein activity was correlated with symptoms of bladder pain and voiding frequency. The percentage of total urinary kallikrein in the active form correlated with active kallikrein levels and was also increased in interstitial cystitis patients, particularly those with higher levels of pain. Patients who underwent hydrodistention and subsequently experienced relief from the bladder symptoms had a decrease in urinary kallikrein levels, whereas patients who failed to improve following hydrodistention did not.

subject areas

  • Adult
  • Aged
  • Aged, 80 and over
  • Amino Acid Sequence
  • Cystitis
  • Enzyme Activation
  • Female
  • Humans
  • Kallikreins
  • Male
  • Middle Aged
  • Molecular Sequence Data
  • Pain
  • Prekallikrein
  • Urination
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Research

keywords

  • KALLIKREIN, BLADDER DISEASES, CYSTITIS, KALLIKREIN-KININ SYSTEM
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Identity

International Standard Serial Number (ISSN)

  • 0022-5347

PubMed ID

  • 8051740
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Additional Document Info

start page

  • 874

end page

  • 878

volume

  • 152

issue

  • 3

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