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Png-1, a nervous system-specific zinc finger gene, identifies regions containing postmitotic neurons during mammalian embryonic development

Academic Article
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Overview

authors

  • Weiner, J. A.
  • Chun, Jerold

publication date

  • May 1997

journal

  • Journal of Comparative Neurology  Journal

abstract

  • To identify genes associated with early postmitotic cortical neurons, gene fragments were examined for expression in postmitotic, but not proliferative, zones of the embryonic murine cortex. Through this approach, a novel member of the zinc finger gene family, containing 6 C2HC fingers, was isolated and named postmitotic neural gene-1, or png-1. Embryonic png-1 expression was: 1) nervous system-specific; 2) restricted to zones containing postmitotic neurons; and 3) detected in all developing neural structures examined. In the cortex, png-1 expression was first observed on embryonic day 11, correlating temporally and spatially with the known generation of the first cortical neurons. Gradients of png-1 expression throughout the embryonic central nervous system further correlated temporally and spatially with known gradients of neuron production. With development, expression remained restricted to postmitotic zones, including those containing newly-postmitotic neurons. Png-1 was also detected within two days of neural retinoic acid induction in P19 cells, and expression increased with further neuronal differentiation. These data implicate png-1 as one of the earliest molecular markers for postmitotic neuronal regions and suggest a function as a panneural transcription factor associated with neuronal differentiation.

subject areas

  • Amino Acid Sequence
  • Animals
  • Embryonic and Fetal Development
  • In Situ Hybridization
  • Mice
  • Molecular Sequence Data
  • Nervous System
  • Neurons
  • Zinc Fingers
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Research

keywords

  • cerebral cortex
  • mouse
  • neurogenesis
  • neuronal differentiation
  • zinc finger
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Identity

International Standard Serial Number (ISSN)

  • 0021-9967

Digital Object Identifier (DOI)

  • 10.1002/(sici)1096-9861(19970505)381:2<130::aid-cne2>3.0.co;2-4

PubMed ID

  • 9130664
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Additional Document Info

start page

  • 130

end page

  • 142

volume

  • 381

issue

  • 2

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