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Bone marrow plasmacytoid dendritic cells can differentiate into myeloid dendritic cells upon virus infection

Academic Article
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Overview

authors

  • Zuniga, E. I.
  • McGavern, Dorian
  • Pruneda-Paz, J. L.
  • Teng, C.
  • Oldstone, Michael

publication date

  • December 2004

journal

  • Nature Immunology  Journal

abstract

  • Two subsets of dendritic cell (DCs), plasmacytoid (p) and myeloid (m) DCs, have been described in humans and mice. These subsets are known to have divergent roles during an immune response, but their developmental course is unclear. Here we report that virus infection induces bone marrow pDCs to differentiate into mDCs, thereby undergoing profound phenotypic and functional changes including the acquisition of enhanced antigen-presenting capacity and the ability to recognize different microbial structures through Toll-like receptor 4. The conversion of pDCs into mDCs is also induced by the injection of double-stranded RNA and requires type I interferons. Our results establish a precursor-product developmental relationship between these two DC subsets and highlight unexpected plasticity of bone marrow pDCs.

subject areas

  • Animals
  • Bone Marrow Cells
  • Cell Differentiation
  • Cell Proliferation
  • Cells, Cultured
  • Dendritic Cells
  • Interferon Type I
  • Kinetics
  • Lymphocytic choriomeningitis virus
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Myeloid Cells
  • Phenotype
  • Reproducibility of Results
  • Spleen
  • Virus Diseases
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Identity

International Standard Serial Number (ISSN)

  • 1529-2908

Digital Object Identifier (DOI)

  • 10.1038/ni1136

PubMed ID

  • 15531885
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Additional Document Info

start page

  • 1227

end page

  • 1234

volume

  • 5

issue

  • 12

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