related to degree

• Siggs, Owen Marc, Ph.D. in Biology, Scripps Research , Joint graduate program with Oxford University 2007 - 2012

authors

• Siggs, Owen Marc
• Li, X. H.
• Xia, Y.
• Beutler, Bruce

publication date

• January 2012

journal

• Journal of Experimental Medicine  Journal

abstract

• In this study, we describe a chemically induced mouse mutation that caused a complete and cell-intrinsic T cell deficiency. Development of other lymphoid lineages was also partially impaired and was severely compromised under competitive conditions. Positional cloning, retroviral transduction, and a somatic reversion event revealed that the causative mutation lay within Zbtb1 (zinc finger and BTB domain containing 1), a gene conserved throughout vertebrate evolution. Our data establish ZBTB1 as a critical determinant of T cell development and lymphopoiesis in general, most likely by acting as a transcriptional regulator.

subject areas

• Amino Acid Sequence
• Animals
• Base Sequence
• Female
• Gene Expression Regulation, Developmental
• Hematopoietic Stem Cells
• Lymphocytes
• Lymphopenia
• Lymphopoiesis
• Male
• Mice
• Mice, Inbred C3H
• Mice, Inbred C57BL
• Molecular Sequence Data
• Mutation
• Myeloid Cells
• Repressor Proteins
• T-Lymphocytes
• Zinc Fingers

PubMed Central ID

• PMC3260866

International Standard Serial Number (ISSN)

• 0022-1007

Digital Object Identifier (DOI)

• 10.1084/jem.20112084

PubMed ID

• 22201126

start page

• 19

end page

• 27

volume

• 209

issue

• 1