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ZBTB1 is a determinant of lymphoid development

Academic Article
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Overview

related to degree

  • Siggs, Owen Marc, Ph.D. in Biology, Scripps Research , Joint graduate program with Oxford University 2007 - 2012

authors

  • Siggs, Owen Marc
  • Li, X. H.
  • Xia, Y.
  • Beutler, Bruce

publication date

  • January 2012

journal

  • Journal of Experimental Medicine  Journal

abstract

  • In this study, we describe a chemically induced mouse mutation that caused a complete and cell-intrinsic T cell deficiency. Development of other lymphoid lineages was also partially impaired and was severely compromised under competitive conditions. Positional cloning, retroviral transduction, and a somatic reversion event revealed that the causative mutation lay within Zbtb1 (zinc finger and BTB domain containing 1), a gene conserved throughout vertebrate evolution. Our data establish ZBTB1 as a critical determinant of T cell development and lymphopoiesis in general, most likely by acting as a transcriptional regulator.

subject areas

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Female
  • Gene Expression Regulation, Developmental
  • Hematopoietic Stem Cells
  • Lymphocytes
  • Lymphopenia
  • Lymphopoiesis
  • Male
  • Mice
  • Mice, Inbred C3H
  • Mice, Inbred C57BL
  • Molecular Sequence Data
  • Mutation
  • Myeloid Cells
  • Repressor Proteins
  • T-Lymphocytes
  • Zinc Fingers
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Identity

PubMed Central ID

  • PMC3260866

International Standard Serial Number (ISSN)

  • 0022-1007

Digital Object Identifier (DOI)

  • 10.1084/jem.20112084

PubMed ID

  • 22201126
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Additional Document Info

start page

  • 19

end page

  • 27

volume

  • 209

issue

  • 1

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