recent publications
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academic article
- Brown, N. E., Goswami, D., Branch, M. R., Ramineni, S., Ortlund, E. A., Griffin, P. R., Hepler, J. R. Integration of G protein a (Ga) signaling by the regulator of G protein signaling 14 (RGS14) Journal of Biological Chemistry 2015 290:9037-9049 DOI:10.1074/jbc.M114.634329 PMID:25666614 PMCID:PMC4423691
- Hudson, W. H., Pickard, M. R., de Vera, I. M. S., Kuiper, E. G., Mourtada-Maarabouni, M., Conn, G. L., Kojetin, D. J., Williams, G. T., Ortlund, E. A. Conserved sequence-specific lincRNA-steroid receptor interactions drive transcriptional repression and direct cell fate Nature Communications 2014 5:5395 DOI:10.1038/ncomms6395 PMID:25377354 PMCID:PMC4280027
- Armstrong, E. H., Goswami, D., Griffin, P. R., Noy, N., Ortlund, E. A. Structural basis for ligand regulation of the fatty acid-binding protein 5, peroxisome proliferator-activated receptor beta/delta (FABP5-PPAR beta/delta) signaling pathway Journal of Biological Chemistry 2014 289:14941-14954 DOI:10.1074/jbc.M113.514646 PMID:24692551 PMCID:PMC4031543
- Qiang, G., Xue, S., Yang, J. J., Du, G., Pang, X., Li, X., Goswami, D., Griffin, P. R., Ortlund, E. A., Chan, C. B., Ye, K. Identification of a small molecular insulin receptor agonist with potent antidiabetes activity Diabetes 2014 63:1394-1409 DOI:10.2337/db13-0334 PMID:24651808 PMCID:PMC3964510
- Musille, P. M., Pathak, M., Lauer, J. L., Griffin, P. R., Ortlund, E. A. Divergent sequence tunes ligand sensitivity in phospholipid-regulated hormone receptors Journal of Biological Chemistry 2013 288:20702-20712 DOI:10.1074/jbc.M113.472837 PMID:23737522 PMCID:PMC3711333
- Harms, M. J., Eick, G. N., Goswami, D., Colucci, J. K., Griffin, P. R., Ortlund, E. A., Thornton, J. W. Biophysical mechanisms for large-effect mutations in the evolution of steroid hormone receptors Proceedings of the National Academy of Sciences of the United States of America 2013 110:11475-11480 DOI:10.1073/pnas.1303930110 PMID:23798447 PMCID:PMC3710831
- Musille, P. M., Pathak, M. C., Lauer, J. L., Hudson, W. H., Griffin, P. R., Ortlund, E. A. Antidiabetic phospholipid-nuclear receptor complex reveals the mechanism for phospholipid-driven gene regulation Nature Structural & Molecular Biology 2012 19:532-7, S1 DOI:10.1038/nsmb.2279 PMID:22504882 PMCID:PMC3960984
- Lee, J. M., Lee, Y. K., Mamrosh, J. L., Busby, S. A., Griffin, P. R., Pathak, M. C., Ortlund, E. A., Moore, D. D. A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects Nature 2011 474:506-510 DOI:10.1038/nature10111 PMID:21614002 PMCID:PMC3150801