recent publications

• academic article

  • Brown, N. E., Goswami, D., Branch, M. R., Ramineni, S., Ortlund, E. A., Griffin, P. R., Hepler, J. R. Integration of G protein a (Ga) signaling by the regulator of G protein signaling 14 (RGS14) Journal of Biological Chemistry  2015 290:9037-9049  DOI:10.1074/jbc.M114.634329  PMID:25666614  PMCID:PMC4423691
  • Hudson, W. H., Pickard, M. R., de Vera, I. M. S., Kuiper, E. G., Mourtada-Maarabouni, M., Conn, G. L., Kojetin, D. J., Williams, G. T., Ortlund, E. A. Conserved sequence-specific lincRNA-steroid receptor interactions drive transcriptional repression and direct cell fate Nature Communications  2014 5:5395  DOI:10.1038/ncomms6395  PMID:25377354  PMCID:PMC4280027
  • Qiang, G., Xue, S., Yang, J. J., Du, G., Pang, X., Li, X., Goswami, D., Griffin, P. R., Ortlund, E. A., Chan, C. B., Ye, K. Identification of a small molecular insulin receptor agonist with potent antidiabetes activity Diabetes  2014 63:1394-1409  DOI:10.2337/db13-0334  PMID:24651808  PMCID:PMC3964510
  • Armstrong, E. H., Goswami, D., Griffin, P. R., Noy, N., Ortlund, E. A. Structural basis for ligand regulation of the fatty acid-binding protein 5, peroxisome proliferator-activated receptor beta/delta (FABP5-PPAR beta/delta) signaling pathway Journal of Biological Chemistry  2014 289:14941-14954  DOI:10.1074/jbc.M113.514646  PMID:24692551  PMCID:PMC4031543
  • Harms, M. J., Eick, G. N., Goswami, D., Colucci, J. K., Griffin, P. R., Ortlund, E. A., Thornton, J. W. Biophysical mechanisms for large-effect mutations in the evolution of steroid hormone receptors Proceedings of the National Academy of Sciences of the United States of America  2013 110:11475-11480  DOI:10.1073/pnas.1303930110  PMID:23798447  PMCID:PMC3710831
  • Musille, P. M., Pathak, M., Lauer, J. L., Griffin, P. R., Ortlund, E. A. Divergent sequence tunes ligand sensitivity in phospholipid-regulated hormone receptors Journal of Biological Chemistry  2013 288:20702-20712  DOI:10.1074/jbc.M113.472837  PMID:23737522  PMCID:PMC3711333
  • Musille, P. M., Pathak, M. C., Lauer, J. L., Hudson, W. H., Griffin, P. R., Ortlund, E. A. Antidiabetic phospholipid-nuclear receptor complex reveals the mechanism for phospholipid-driven gene regulation Nature Structural & Molecular Biology  2012 19:532-7, S1  DOI:10.1038/nsmb.2279  PMID:22504882  PMCID:PMC3960984
  • Lee, J. M., Lee, Y. K., Mamrosh, J. L., Busby, S. A., Griffin, P. R., Pathak, M. C., Ortlund, E. A., Moore, D. D. A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects Nature  2011 474:506-510  DOI:10.1038/nature10111  PMID:21614002  PMCID:PMC3150801