Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Exploratory, anxiety and spatial memory impairments are dissociated in mice lacking the LPA1 receptor

Academic Article
uri icon
  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Castilla-Ortega, E.
  • Sanchez-Lopez, J.
  • Hoyo-Becerra, C.
  • Matas-Rico, E.
  • Zambrana-Infantes, E.
  • Chun, Jerold
  • De Fonseca, F. R.
  • Pedraza, C.
  • Estivill-Torrus, G.
  • Santin, L. J.

publication date

  • July 2010

journal

  • Neurobiology of Learning and Memory  Journal

abstract

  • Lysophosphatidic acid (LPA) is a new, intercellular signalling molecule in the brain that has an important role in adult hippocampal plasticity. Mice lacking the LPA(1) receptor exhibit motor, emotional and cognitive alterations. However, the potential relationship among these concomitant impairments was unclear. Wild-type and maLPA(1)-null mice were tested on the hole-board for habituation and spatial learning. MaLPA(1)-null mice exhibited reduced exploration in a novel context and a defective intersession habituation that also revealed increased anxiety-like behaviour throughout the hole-board testing. In regard to spatial memory, maLPA(1) nulls failed to reach the controls' performance at the end of the reference memory task. Moreover, their defective working memory on the first training day suggested a delayed acquisition of the task's working memory rule, which is also a long term memory component. The temporal interval between trials and the task's difficulty may explain some of the deficits found in these mice. Principal components analysis revealed that alterations found in each behavioural dimension were independent. Therefore, exploratory and emotional impairments did not account for the cognitive deficits that may be attributed to maLPA(1) nulls' hippocampal malfunction.

subject areas

  • Animals
  • Anxiety
  • Exploratory Behavior
  • Habituation, Psychophysiologic
  • Male
  • Memory
  • Memory Disorders
  • Memory, Short-Term
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Motor Activity
  • Neuropsychological Tests
  • Principal Component Analysis
  • Receptors, Lysophosphatidic Acid
  • Space Perception
  • Time Factors
scroll to property group menus

Research

keywords

  • Habituation
  • Hole-board
  • Knockout mice
  • Lysophosphatidic acid
  • Principal components factorial analysis
  • Spatial reference memory
  • Spatial working memory
scroll to property group menus

Identity

PubMed Central ID

  • PMC3684252

International Standard Serial Number (ISSN)

  • 1074-7427

Digital Object Identifier (DOI)

  • 10.1016/j.nlm.2010.04.003

PubMed ID

  • 20388543
scroll to property group menus

Additional Document Info

start page

  • 73

end page

  • 82

volume

  • 94

issue

  • 1

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support