recent publications

• academic article

  • Bopp, S. E. R., Manary, M. J., Bright, A. T., Johnston, G. L., Dharia, N. V., Luna, F. L., McCormack, S., Plouffe, D., McNamara, C. W., Walker, J. R., Fidock, D. A., Denchi, E. L., et al. Mitotic evolution of Plasmodium falciparum shows a stable core genome but recombination in antigen families PLoS Genetics  2013 9:e1003293  DOI:10.1371/journal.pgen.1003293  PMID:23408914  PMCID:PMC3567157
  • Nagle, A., Wu, T., Kuhen, K., Gagaring, K., Borboa, R., Francek, C., Chen, Z., Plouffe, D., Lin, X. N., Caldwell, C., Ek, J., Skolnik, S., et al. Imidazolopiperazines: Lead optimization of the second-generation antimalarial agents Journal of Medicinal Chemistry  2012 55:4244-4273  DOI:10.1021/jm300041e  PMID:22524250  PMCID:PMC3350218
  • Delves, M., Plouffe, D., Scheurer, C., Meister, S., Wittlin, S., Winzeler, E. A., Sinden, R. E., Leroy, D. The activities of current antimalarial drugs on the life cycle stages of plasmodium: A comparative study with human and rodent parasites PLoS Medicine  2012 9:e1001169  DOI:10.1371/journal.pmed.1001169  PMID:22363211  PMCID:PMC3283556
  • Wu, T., Nagle, A., Kuhen, K., Gagaring, K., Borboa, R., Francek, C., Chen, Z., Plouffe, D., Goh, A., Lakshminarayana, S. B., Wu, J., Ang, H. Q., et al. Imidazolopiperazines: Hit to lead optimization of new antimalarial agents Journal of Medicinal Chemistry  2011 54:5116-5130  DOI:10.1021/jm2003359  PMID:21644570
  • Deng, X. M., Nagle, A., Wu, T., Sakata, T., Henson, K., Chen, Z., Kuhen, K., Plouffe, D., Winzeler, E., Adrian, F., Tuntland, T., Chang, J., et al. Discovery of novel 1h-imidazol-2-yl-pyrimidine-4,6-diamines as potential antimalarials Bioorganic & Medicinal Chemistry Letters  2010 20:4027-4031  DOI:10.1016/j.bmcl.2010.05.095  PMID:20610151
  • Dharia, N. V., Plouffe, D., Bopp, S. E. R., Gonzalez-Paez, G. E., Lucas, C., Salas, C., Soberon, V., Bursulaya, B., Kochel, T. J., Bacon, D. J., Winzeler, E. A. Genome scanning of amazonian plasmodium falciparum shows subtelomeric instability and clindamycin-resistant parasites Genome Research  2010 20:1534-1544  DOI:10.1101/gr.105163.110  PMID:20829224  PMCID:PMC2963817
  • Yeung, B. K. S., Zou, B., Rottmann, M., Lakshminarayana, S. B., Ang, S. H., Leong, S. Y., Tan, J., Wong, J., Keller-Maerki, S., Fischli, C., Goh, A., Schmitt, E. K., et al. Spirotetrahydro beta-carbolines (spiroindolones): A new class of potent and orally efficacious compounds for the treatment of malaria Journal of Medicinal Chemistry  2010 53:5155-5164  DOI:10.1021/jm100410f  PMID:20568778
  • Wu, T., Nagle, A., Sakata, T., Henson, K., Borboa, R., Chen, Z., Kuhen, K., Plouffe, D., Winzeler, E., Adrian, F., Tuntland, T., Chang, J., et al. Cell-based optimization of novel benzamides as potential antimalarial leads Bioorganic & Medicinal Chemistry Letters  2009 19:6970-6974  DOI:10.1016/j.bmcl.2009.10.050  PMID:19879133  PMCID:PMC3532596
  • Dharia, N. V., Sidhu, A. B. S., Cassera, M. B., Westenberger, S. J., Bopp, S. E. R., Eastman, R. T., Plouffe, D., Batalov, S., Park, D. J., Volkman, S. K., Wirth, D. F., Zhou, Y. Y., et al. Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in plasmodium falciparum Genome Biology  2009 10:R21  DOI:10.1186/gb-2009-10-2-r21  PMID:19216790  PMCID:PMC2688282
  • Le Roch, K. G., Johnson, J. R., Ahiboh, H., Chung, D. W. D., Prudhomme, J., Plouffe, D., Henson, K., Zhou, Y. Y., Witola, W., Yates, J. R., Ben Mamoun, C., Winzeler, E. A., et al. A systematic approach to understand the mechanism of action of the bisthiazolium compound T4 on the human malaria parasite, Plasmodium falciparum BMC Genomics  2008 9:513  DOI:10.1186/1471-2164-9-513  PMID:18973684  PMCID:PMC2596145
  • Zhou, Y. Y., Ramachandran, V., Kumar, K. A., Westenberger, S., Refour, P., Zhou, B., Li, F. W., Young, J. A., Chen, K. S., Plouffe, D., Henson, K., Nussenzweig, V., et al. Evidence-based annotation of the malaria parasite's genome using comparative expression profiling PLoS One  2008 3:e1570  DOI:10.1371/journal.pone.0001570  PMID:18270564  PMCID:PMC2215772
  • Kato, N., Sakata, T., Breton, G., Le Roch, K. G., Nagle, A., Andersen, C., Bursulaya, B., Henson, K., Johnson, J., Kumar, K. A., Marr, F., Mason, D., et al. Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility Nature Chemical Biology  2008 4:347-356  DOI:10.1038/nchembio.87  PMID:18454143
  • Plouffe, D., Brinker, A., McNamara, C., Henson, K., Kato, N., Kuhen, K., Nagle, A., Adrian, F., Matzen, J. T., Anderson, P., Nam, T. G., Gray, N. S., et al. In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen Proceedings of the National Academy of Sciences of the United States of America  2008 105:9059-9064  DOI:10.1073/pnas.0802982105  PMID:18579783  PMCID:PMC2440361
  • Daily, J. P., Scanfeld, D., Pochet, N., Le Roch, K., Plouffe, D., Kamal, M., Sarr, O., Mboup, S., Ndir, O., Wypij, D., Levasseur, K., Tamayo, P. Distinct physiological states of plasmodium falciparum in malaria-infected patients Nature  2007 450:1091-1095  DOI:10.1038/nature06311  PMID:18046333
  • Kidgell, C., Volkman, S. K., Daily, J., Borevitz, J. O., Plouffe, D., Zhou, Y. Y., Johnson, J. R., Le Roch, K. G., Sarr, O., Ndir, O., Mboup, S., Batalov, S., et al. A systematic map of genetic variation in plasmodium falciparum PLoS Pathogens  2006 2:562-577  DOI:10.1371/journal.ppat.0020057  PMID:16789840  PMCID:PMC1480597
  • Stubbs, J., Simpson, K. M., Triglia, T., Plouffe, D., Tonkin, C. J., Duraisingh, M. T., Maier, A. G., Winzeler, E. A., Cowman, A. F. Molecular mechanism for switching of p-falciparum invasion pathways into human erythrocytes Science  2005 309:1384-1387  DOI:10.1126/science.1115257  PMID:16123303
  • Borevitz, J. O., Liang, D., Plouffe, D., Chang, H. S., Zhu, T., Weigel, D., Berry, C. C., Winzeler, E., Chory, J. Large-scale identification of single-feature polymorphisms in complex genomes Genome Research  2003 13:513-523  DOI:10.1101/gr.541303  PMID:12618383  PMCID:PMC430246
  • Washburn, M. P., Koller, A., Oshiro, G., Ulaszek, R. R., Plouffe, D., Deciu, C., Winzeler, E., Yates, J. R. Protein pathway and complex clustering of correlated mRNA and protein expression analyses in Saccharomyces cerevisiae Proceedings of the National Academy of Sciences of the United States of America  2003 100:3107-3112  DOI:10.1073/pnas.0634629100  PMID:12626741  PMCID:PMC152254
  • Volkman, S. K., Hartl, D. L., Wirth, D. F., Nielsen, K. M., Choi, M., Batalov, S., Zhou, Y. Y., Plouffe, D., Le Roch, K. G., Abagyan, R., Winzeler, E. A. Excess polymorphisms in genes for membrane proteins in plasmodium falciparum Science  2002 298:216-218  DOI:10.1126/science.1075642  PMID:12364807