recent publications
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academic article
- Bopp, S. E. R., Manary, M. J., Bright, A. T., Johnston, G. L., Dharia, N. V., Luna, F. L., McCormack, S., Plouffe, D., McNamara, C. W., Walker, J. R., Fidock, D. A., Denchi, E. L., et al. Mitotic evolution of Plasmodium falciparum shows a stable core genome but recombination in antigen families PLoS Genetics 2013 9:e1003293 DOI:10.1371/journal.pgen.1003293 PMID:23408914 PMCID:PMC3567157
- Nagle, A., Wu, T., Kuhen, K., Gagaring, K., Borboa, R., Francek, C., Chen, Z., Plouffe, D., Lin, X. N., Caldwell, C., Ek, J., Skolnik, S., et al. Imidazolopiperazines: Lead optimization of the second-generation antimalarial agents Journal of Medicinal Chemistry 2012 55:4244-4273 DOI:10.1021/jm300041e PMID:22524250 PMCID:PMC3350218
- Delves, M., Plouffe, D., Scheurer, C., Meister, S., Wittlin, S., Winzeler, E. A., Sinden, R. E., Leroy, D. The activities of current antimalarial drugs on the life cycle stages of plasmodium: A comparative study with human and rodent parasites PLoS Medicine 2012 9:e1001169 DOI:10.1371/journal.pmed.1001169 PMID:22363211 PMCID:PMC3283556
- Wu, T., Nagle, A., Kuhen, K., Gagaring, K., Borboa, R., Francek, C., Chen, Z., Plouffe, D., Goh, A., Lakshminarayana, S. B., Wu, J., Ang, H. Q., et al. Imidazolopiperazines: Hit to lead optimization of new antimalarial agents Journal of Medicinal Chemistry 2011 54:5116-5130 DOI:10.1021/jm2003359 PMID:21644570
- Dharia, N. V., Plouffe, D., Bopp, S. E. R., Gonzalez-Paez, G. E., Lucas, C., Salas, C., Soberon, V., Bursulaya, B., Kochel, T. J., Bacon, D. J., Winzeler, E. A. Genome scanning of amazonian plasmodium falciparum shows subtelomeric instability and clindamycin-resistant parasites Genome Research 2010 20:1534-1544 DOI:10.1101/gr.105163.110 PMID:20829224 PMCID:PMC2963817
- Yeung, B. K. S., Zou, B., Rottmann, M., Lakshminarayana, S. B., Ang, S. H., Leong, S. Y., Tan, J., Wong, J., Keller-Maerki, S., Fischli, C., Goh, A., Schmitt, E. K., et al. Spirotetrahydro beta-carbolines (spiroindolones): A new class of potent and orally efficacious compounds for the treatment of malaria Journal of Medicinal Chemistry 2010 53:5155-5164 DOI:10.1021/jm100410f PMID:20568778
- Deng, X. M., Nagle, A., Wu, T., Sakata, T., Henson, K., Chen, Z., Kuhen, K., Plouffe, D., Winzeler, E., Adrian, F., Tuntland, T., Chang, J., et al. Discovery of novel 1h-imidazol-2-yl-pyrimidine-4,6-diamines as potential antimalarials Bioorganic & Medicinal Chemistry Letters 2010 20:4027-4031 DOI:10.1016/j.bmcl.2010.05.095 PMID:20610151
- Wu, T., Nagle, A., Sakata, T., Henson, K., Borboa, R., Chen, Z., Kuhen, K., Plouffe, D., Winzeler, E., Adrian, F., Tuntland, T., Chang, J., et al. Cell-based optimization of novel benzamides as potential antimalarial leads Bioorganic & Medicinal Chemistry Letters 2009 19:6970-6974 DOI:10.1016/j.bmcl.2009.10.050 PMID:19879133 PMCID:PMC3532596
- Dharia, N. V., Sidhu, A. B. S., Cassera, M. B., Westenberger, S. J., Bopp, S. E. R., Eastman, R. T., Plouffe, D., Batalov, S., Park, D. J., Volkman, S. K., Wirth, D. F., Zhou, Y. Y., et al. Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in plasmodium falciparum Genome Biology 2009 10:R21 DOI:10.1186/gb-2009-10-2-r21 PMID:19216790 PMCID:PMC2688282
- Le Roch, K. G., Johnson, J. R., Ahiboh, H., Chung, D. W. D., Prudhomme, J., Plouffe, D., Henson, K., Zhou, Y. Y., Witola, W., Yates, J. R., Ben Mamoun, C., Winzeler, E. A., et al. A systematic approach to understand the mechanism of action of the bisthiazolium compound T4 on the human malaria parasite, Plasmodium falciparum BMC Genomics 2008 9:513 DOI:10.1186/1471-2164-9-513 PMID:18973684 PMCID:PMC2596145
- Plouffe, D., Brinker, A., McNamara, C., Henson, K., Kato, N., Kuhen, K., Nagle, A., Adrian, F., Matzen, J. T., Anderson, P., Nam, T. G., Gray, N. S., et al. In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen Proceedings of the National Academy of Sciences of the United States of America 2008 105:9059-9064 DOI:10.1073/pnas.0802982105 PMID:18579783 PMCID:PMC2440361
- Kato, N., Sakata, T., Breton, G., Le Roch, K. G., Nagle, A., Andersen, C., Bursulaya, B., Henson, K., Johnson, J., Kumar, K. A., Marr, F., Mason, D., et al. Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility Nature Chemical Biology 2008 4:347-356 DOI:10.1038/nchembio.87 PMID:18454143
- Zhou, Y. Y., Ramachandran, V., Kumar, K. A., Westenberger, S., Refour, P., Zhou, B., Li, F. W., Young, J. A., Chen, K. S., Plouffe, D., Henson, K., Nussenzweig, V., et al. Evidence-based annotation of the malaria parasite's genome using comparative expression profiling PLoS One 2008 3:e1570 DOI:10.1371/journal.pone.0001570 PMID:18270564 PMCID:PMC2215772
- Daily, J. P., Scanfeld, D., Pochet, N., Le Roch, K., Plouffe, D., Kamal, M., Sarr, O., Mboup, S., Ndir, O., Wypij, D., Levasseur, K., Tamayo, P. Distinct physiological states of plasmodium falciparum in malaria-infected patients Nature 2007 450:1091-1095 DOI:10.1038/nature06311 PMID:18046333
- Kidgell, C., Volkman, S. K., Daily, J., Borevitz, J. O., Plouffe, D., Zhou, Y. Y., Johnson, J. R., Le Roch, K. G., Sarr, O., Ndir, O., Mboup, S., Batalov, S., et al. A systematic map of genetic variation in plasmodium falciparum PLoS Pathogens 2006 2:562-577 DOI:10.1371/journal.ppat.0020057 PMID:16789840 PMCID:PMC1480597
- Stubbs, J., Simpson, K. M., Triglia, T., Plouffe, D., Tonkin, C. J., Duraisingh, M. T., Maier, A. G., Winzeler, E. A., Cowman, A. F. Molecular mechanism for switching of p-falciparum invasion pathways into human erythrocytes Science 2005 309:1384-1387 DOI:10.1126/science.1115257 PMID:16123303
- Washburn, M. P., Koller, A., Oshiro, G., Ulaszek, R. R., Plouffe, D., Deciu, C., Winzeler, E., Yates, J. R. Protein pathway and complex clustering of correlated mRNA and protein expression analyses in Saccharomyces cerevisiae Proceedings of the National Academy of Sciences of the United States of America 2003 100:3107-3112 DOI:10.1073/pnas.0634629100 PMID:12626741 PMCID:PMC152254
- Borevitz, J. O., Liang, D., Plouffe, D., Chang, H. S., Zhu, T., Weigel, D., Berry, C. C., Winzeler, E., Chory, J. Large-scale identification of single-feature polymorphisms in complex genomes Genome Research 2003 13:513-523 DOI:10.1101/gr.541303 PMID:12618383 PMCID:PMC430246
- Volkman, S. K., Hartl, D. L., Wirth, D. F., Nielsen, K. M., Choi, M., Batalov, S., Zhou, Y. Y., Plouffe, D., Le Roch, K. G., Abagyan, R., Winzeler, E. A. Excess polymorphisms in genes for membrane proteins in plasmodium falciparum Science 2002 298:216-218 DOI:10.1126/science.1075642 PMID:12364807