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Inhibition of Epstein-Barr virus-mediated capping of CD21 CR-2 by alpha-interferon (IFN-alpha) - immediate antiviral activity of IFN-alpha during the early phase of infection

Academic Article
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Overview

authors

  • Delcayre, A. X.
  • Lotz, Martin
  • Lernhardt, W.

publication date

  • May 1993

journal

  • Journal of Virology  Journal

abstract

  • Early events of human B-lymphocyte infection by Epstein-Barr virus involve the virus binding to CD21, capping, and subsequent internalization of the virus-receptor complex. We show here that alpha interferon (IFN-alpha) inhibits the capping of Epstein-Barr virus-CD21 complexes. Synthetic peptides with the CD21 binding motif of IFN-alpha mimic IFN-alpha activity, suggesting that this effect may be mediated by IFN-alpha-CD21 interaction. Our findings demonstrate a novel and immediate mechanism of IFN-alpha action.

subject areas

  • B-Lymphocytes
  • Binding, Competitive
  • Herpesvirus 4, Human
  • Humans
  • Interferon-alpha
  • Peptide Fragments
  • Receptors, Complement 3d
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Identity

PubMed Central ID

  • PMC237619

International Standard Serial Number (ISSN)

  • 0022-538X

PubMed ID

  • 8386282
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Additional Document Info

start page

  • 2918

end page

  • 2921

volume

  • 67

issue

  • 5

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