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Challenges in the phenotypic characterisation of patients in genetic studies of coronary artery disease

Academic Article
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Overview

authors

  • Luo, A. K.
  • Jefferson, B. K.
  • Garcia, M. J.
  • Ginsburg, G. S.
  • Topol, Eric

publication date

  • March 2007

journal

  • Journal of Medical Genetics  Journal

abstract

  • Coronary artery disease and acute myocardial infarction are complex traits in which there has been recent research to identify the principal genes that engender susceptibility or provide protection. Although there has been exceptional progress in the technology, which now allows genotyping of hundreds of thousands of single-nucleotide polymorphisms in each individual, there remains a pattern of inconsistency in the studies performed to date, in part owing to the difficulties in defining cases and controls. In this paper, salient issues to facilitate research in this important field are reviewed.

subject areas

  • Adolescent
  • Adult
  • Age of Onset
  • Aged
  • Angina Pectoris
  • Calcinosis
  • Case-Control Studies
  • Comorbidity
  • Coronary Angiography
  • Coronary Artery Disease
  • Coronary Disease
  • Female
  • Forecasting
  • Genetic Linkage
  • Genetic Predisposition to Disease
  • Humans
  • Male
  • Middle Aged
  • Myocardial Infarction
  • Patient Selection
  • Phenotype
  • Polymorphism, Single Nucleotide
  • Tomography, X-Ray Computed
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Identity

PubMed Central ID

  • PMC2598022

International Standard Serial Number (ISSN)

  • 0022-2593

Digital Object Identifier (DOI)

  • 10.1136/jmg.2006.045732

PubMed ID

  • 17158593
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Additional Document Info

start page

  • 161

end page

  • 165

volume

  • 44

issue

  • 3

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