related to degree

• Rodriguez, Rodrigo, Ph.D. in Chemistry, Scripps Research 2008 - 2014

authors

• Su, S.
• Rodriguez, Rodrigo
• Baran, Phil

publication date

• September 2011

journal

• Journal of the American Chemical Society  Journal

abstract

• The development of a simple, efficient, scalable, and stereocontrolled synthesis of a common intermediate en route to the axinellamines, massadines, and palau'amine is reported. This completely new route was utilized to prepare the axinellamines on a gram scale. In a more general sense, three distinct and enabling methodological advances were made during these studies: (1) an ethylene glycol-assisted Pauson-Khand cycloaddition reaction, (2) a Zn/In-mediated Barbier-type reaction, and (3) a TfNH(2)-assisted chlorination-spirocyclization.

subject areas

• Chemistry Techniques, Synthetic
• Guanidines
• Imidazoles
• Pyrroles
• Spiro Compounds
• Stereoisomerism

PubMed Central ID

• PMC3164937

International Standard Serial Number (ISSN)

• 0002-7863

Digital Object Identifier (DOI)

• 10.1021/ja206191g

PubMed ID

• 21846138

start page

• 13922

end page

• 13925

volume

• 133

issue

• 35