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A genome-wide search for chromosomal loci linked to mental health wellness in relatives at high risk for bipolar affective disorder among the old order amish

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Overview

authors

  • Ginns, E. I.
  • St Jean, P.
  • Philibert, R. A.
  • Galdzicka, M.
  • Damschroder-Williams, P.
  • Thiel, B.
  • Long, R. T.
  • Ingraham, L. J.
  • Dalwaldi, H.
  • Murray, M. A.
  • Ehlert, M.
  • Paul, S.
  • Remortel, B. G.
  • Patel, A. P.
  • Anderson, M. C. H.
  • Shaio, C.
  • Lau, E.
  • Dymarskaia, I.
  • Martin, B. M.
  • Stubblefield, B.
  • Falls, K. M.
  • Carulli, J. P.
  • Keith, T. P.
  • Fann, C. S. J.
  • Lacy, L. G.
  • Allen, C. R.
  • Hostetter, A. M.
  • Elston, R. C.
  • Schork, Nicholas
  • Egeland, J. A.
  • Paul, S. M.

publication date

  • December 1998

journal

  • Proceedings of the National Academy of Sciences of the United States of America  Journal

abstract

  • Bipolar affective disorder (BPAD; manic-depressive illness) is characterized by episodes of mania and/or hypomania interspersed with periods of depression. Compelling evidence supports a significant genetic component in the susceptibility to develop BPAD. To date, however, linkage studies have attempted only to identify chromosomal loci that cause or increase the risk of developing BPAD. To determine whether there could be protective alleles that prevent or reduce the risk of developing BPAD, similar to what is observed in other genetic disorders, we used mental health wellness (absence of any psychiatric disorder) as the phenotype in our genome-wide linkage scan of several large multigeneration Old Order Amish pedigrees exhibiting an extremely high incidence of BPAD. We have found strong evidence for a locus on chromosome 4p at D4S2949 (maximum GENEHUNTER-PLUS nonparametric linkage score = 4.05, P = 5. 22 x 10(-4); SIBPAL Pempirical value <3 x 10(-5)) and suggestive evidence for a locus on chromosome 4q at D4S397 (maximum GENEHUNTER-PLUS nonparametric linkage score = 3.29, P = 2.57 x 10(-3); SIBPAL Pempirical value <1 x 10(-3)) that are linked to mental health wellness. These findings are consistent with the hypothesis that certain alleles could prevent or modify the clinical manifestations of BPAD and perhaps other related affective disorders.

subject areas

  • Adult
  • Bipolar Disorder
  • Christianity
  • Chromosome Mapping
  • Chromosomes, Human, Pair 4
  • DNA
  • Ethnic Groups
  • Genetic Linkage
  • Genetic Markers
  • Genotype
  • Humans
  • Mental Health
  • Middle Aged
  • Pennsylvania
  • Polymerase Chain Reaction
  • Risk Factors
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Identity

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.95.26.15531

PubMed ID

  • 9861003
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Additional Document Info

start page

  • 15531

end page

  • 15536

volume

  • 95

issue

  • 26

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