recent publications

• academic article

  • Rao, F. W., Chiron, S., Wei, Z. Y., Fung, M. M., Chen, Y. Q., Wen, G., Khandrika, S., Ziegler, M. G., Benyamin, B., Montgomery, G., Whitfield, J. B., Martin, N. G., et al. Genetic variation within a metabolic motif in the chromogranin a promoter: Pleiotropic influence on cardiometabolic risk traits in twins American Journal of Hypertension  2012 25:29-40  DOI:10.1038/ajh.2011.163  PMID:21918574  PMCID:PMC3664223
  • Chen, Y. Q., Zhang, K. X., Wen, G., Rao, F. W., Sanchez, A. P., Wang, L., Rodriguez-Flores, J. L., Mahata, M., Mahata, S. K., Waalen, J., Ziegler, M. G., Hamilton, B. A., et al. Human dopamine beta-hydroxylase promoter variant alters transcription in chromaffin cells, enzyme secretion, and blood pressure American Journal of Hypertension  2011 24:24-32  DOI:10.1038/ajh.2010.186  PMID:20814407  PMCID:PMC4906639
  • Chen, Y. Q., Wen, G., Rao, F. W., Zhang, K. X., Wang, L., Rodriguez-Flores, J. L., Sanchez, A. P., Mahata, M., Taupenot, L., Sun, P., Mahata, S. K., Tayo, B., et al. Human dopamine beta-hydroxylase (DBH) regulatory polymorphism that influences enzymatic activity, autonomic function, and blood pressure Journal of Hypertension  2010 28:76-86  DOI:10.1097/HJH.0b013e328332bc87  PMID:20009769  PMCID:PMC2860271
  • Chen, Y. Q., Rao, F. W., Rodriguez-Flores, J. L., Mahata, M., Fung, M. M., Stridsberg, M., Vaingankar, S. M., Wen, G., Salem, R. M., Das, M., Cockburn, M. G., Schork, N. J., et al. Naturally occurring human genetic variation in the 3 '-untranslated region of the secretory protein chromogranin a is associated with autonomic blood pressure regulation and hypertension in a sex-dependent fashion Journal of the American College of Cardiology  2008 52:1468-1481  DOI:10.1016/j.jacc.2008.07.047  PMID:19017515  PMCID:PMC2659417
  • Chen, Y., Rao, F., Rodriguez-Flores, J. L., Mahapatra, N. R., Mahata, M., Wen, G., Salem, R. M., Shih, P. A. B., Das, M., Schork, N. J., Ziegler, M. G., Hamilton, B. A., et al. Common genetic variants in the chromogranin a promoter alter autonomic activity and blood pressure Kidney International  2008 74:115-125  DOI:10.1038/ki.2008.113  PMID:18432188  PMCID:PMC2576285
  • Salem, R. M., Cadman, P. E., Chen, Y., Rao, F., Wen, G., Harnilton, B. A., Rana, B. K., Smith, D. W., Stridsberg, M., Ward, H. J., Mahata, M., Mahata, S. K., et al. Chromogranin a polymorphisms are associated with hypertensive renel disease Journal of the American Society of Nephrology  2008 19:600-614  DOI:10.1681/asn.2007070754  PMID:18235090  PMCID:PMC2391050
  • Mosley, C. A., Taupenot, L., Biswas, N., Taulane, J. P., Olson, N. H., Vaingankar, S. M., Wen, G., Schork, N. J., Ziegler, M. G., Mahata, S. K., O'Connor, D. T. Biogenesis of the secretory granule: Chromogranin a coiled-coil structure results in unusual physical properties and suggests a mechanism for granule core condensation Biochemistry  2007 46:10999-11012  DOI:10.1021/bi700704r  PMID:17718510
  • Rao, F., Zhang, L., Wessel, J., Zhang, K., Wen, G., Kennedy, B. P., Rana, B. K., Das, M., Rodriguez-Flores, J. L., Smith, D. W., Cadman, P. E., Salem, R. M., et al. Tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis - discovery of common human genetic variants governing transcription, autonomic activity, and blood pressure in vivo Circulation  2007 116:993-1006  DOI:10.1161/circulationaha.106.682302  PMID:17698732
  • Wen, G., Wessel, J., Zhou, W., Ehret, G. B., Rao, F., Stridsberg, M., Mahata, S. K., Gent, P. M., Das, M., Cooper, R. S., Chakravarti, A., Zhou, H., et al. An ancestral variant of secretogranin ii confers regulation by phox2 transcription factors and association with hypertension Human Molecular Genetics  2007 16:1752-1764  DOI:10.1093/hmg/ddm123  PMID:17584765  PMCID:PMC2695823
  • Rao, F., Wen, G., Gayen, J. R., Das, M., Vaingankar, S. M., Rana, B. K., Mahata, M., Kennedy, B. P., Salem, R. M., Stridsberg, M., Abel, K., Smith, D. W., et al. Catecholamine release-inhibitory peptide catestatin (chromogranin a(352-372)) - naturally occurring amino acid variant gly364ser causes profound changes in human autonomic activity and alters risk for hypertension Circulation  2007 115:2271-2281  DOI:10.1161/circulationaha.106.628859  PMID:17438154
  • Lillie, E. O., Mahata, M., Khandrika, S., Rao, F., Bundey, R. A., Wen, G., Chen, Y. Q., Taupenot, L., Smith, D. W., Mahata, S. K., Ziegler, M. G., Cockburn, M., et al. Heredity of endothelin secretion - human twin studies reveal the influence of polymorphism at the chromogranin a locus, a novel determinant of endothelial function Circulation  2007 115:2282-2291  DOI:10.1161/circulationaha.106.648345  PMID:17438153
  • Rao, F. W., Wessel, J., Wen, G., Zhang, L., Rana, B. K., Kennedy, B. P., Greenwood, T. A., Salem, R. M., Chen, Y. Q., Khandrika, S., Hamilton, B. A., Smith, D. W., et al. Renal albumin excretion - twin studies identify influences of heredity, environment, and adrenergic pathway polymorphism Hypertension  2007 49:1015-1031  DOI:10.1161/hypertensionaha.106.081679  PMID:17353515
  • Wessel, J., Moratorio, G., Rao, F., Mahata, M., Zhang, L., Greene, W., Rana, B. K., Kennedy, B. P., Khandrika, S., Huang, P., Lillie, E. O., Shih, P. A. B., et al. C-reactive protein, an 'intermediate phenotype' for inflammation: Human twin studies reveal heritability, association with blood pressure and the metabolic syndrome, and the influence of common polymorphism at catecholaminergic/beta-adrenergic pathway loci Journal of Hypertension  2007 25:329-343  DOI:10.1097/HJH.0b013e328011753e  PMID:17211240
  • Etzel, J. P., Rana, B. K., Wen, G., Parmer, R. J., Schork, N. J., O'Connor, D. T., Insel, P. A. Genetic variation at the human alpha(2b)-adrenergic receptor locus - role in blood pressure variation and yohimbine response Hypertension  2005 45:1207-1213  DOI:10.1161/01.hyp.0000166721.42734.49  PMID:15920038
  • Wen, G., Mahata, S. K., Cadman, P., Mahata, M., Ghosh, S., Mahapatra, N. R., Rao, F. W., Stridsberg, M., Smith, D. W., Mahboubi, P., Schork, N. J., O'Connor, D. T., et al. Both rare and common polymorphisms contribute functional variation at chga, a regulator of catecholamine physiology American Journal of Human Genetics  2004 74:197-207  DOI:10.1086/381399  PMID:14740315  PMCID:PMC1181918