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Homeostasis of v(alpha)14i nkt cells

Academic Article
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Overview

authors

  • Matsuda, J. L.
  • Gapin, L.
  • Sidobre, S.
  • Kieper, W. C.
  • Tan, J. Y. T.
  • Ceredig, R.
  • Surh, Charles
  • Kronenberg, M.

publication date

  • October 2002

journal

  • Nature Immunology  Journal

abstract

  • CD1d-reactive natural killer T (NKT) cells with an invariant V alpha 14 rearrangement (V alpha 14i) are a distinct subset of T lymphocytes that likely have important immune-regulatory functions. Little is known regarding the factors responsible for their peripheral survival. Using alpha-galactosylceramide-containing CD1d tetramers to detect V alpha 14i NKT cells, we show here that the expansion of V alpha 14i NKT cells in lymphopenic mice was not dependent on CD1d expression and was unaffected by the presence of host NKT cells. Additionally, we found that IL-15 was important in the expansion and/or survival of V alpha 14i NKT cells, with IL-7 playing a lesser role. These results demonstrate that the homeostatic requirements for CD1d-restricted NKT cells, which are CD4(+) or CD4(-)CD8(-), resemble those of CD8(+) memory T cells. We propose that this expansion and/or survival in the periphery of V alpha 14i NKT cells is affected by competition for IL-15, and that IL-15-requiring cells-such as NK cells and CD8(+) memory cells-may define the V alpha 14i NKT cell niche.

subject areas

  • Animals
  • Antigens, CD1
  • Antigens, CD1d
  • Antigens, Differentiation, B-Lymphocyte
  • Cell Division
  • Histocompatibility Antigens Class II
  • Homeostasis
  • Interleukin-15
  • Interleukin-7
  • Killer Cells, Natural
  • Lymphopenia
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • T-Lymphocytes
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Identity

International Standard Serial Number (ISSN)

  • 1529-2908

Digital Object Identifier (DOI)

  • 10.1038/ni837

PubMed ID

  • 12244311
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Additional Document Info

start page

  • 966

end page

  • 974

volume

  • 3

issue

  • 10

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