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Quantitative trait loci mapping for cholesterol gallstones in akr/j and c57l/j strains of mice

Academic Article
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Overview

authors

  • Paigen, B.
  • Schork, Nicholas
  • Svenson, K. L.
  • Cheah, Y. C.
  • Mu, J. L.
  • Lammert, F.
  • Wang, D. Q. H.
  • Bouchard, G.
  • Carey, M. C.

publication date

  • November 2000

journal

  • Physiological Genomics  Journal

abstract

  • Quantitative trait locus (QTL) mapping was used to locate genes that determine the difference in cholesterol gallstone disease between the gallstone-susceptible strain C57L/J and the gallstone-resistant strain AKR/J. Gallstone weight was determined in 231 male (AKR x C57L) F(1) x AKR backcross mice fed a lithogenic diet containing 1% cholesterol, 0.5% cholic acid, and 15% butterfat for 8 wk. Mice having no stones and mice having the largest stones were genotyped at approximately 20-cM intervals to find the loci determining cholesterol gallstone formation. The major locus, Lith1, mapped near D2Mit56 and was confirmed by constructing a congenic strain, AK. L-Lith1(s). Another locus, Lith2, mapped near D19Mit58 and was also confirmed by constructing a congenic strain AK.L-Lith2(s). Other suggestive, but not statistically significant, loci mapped to chromosomes 6, 7, 8, 10, and X. The identification of these Lith genes will elucidate the pathophysiology of cholesterol gallstone formation.

subject areas

  • Animals
  • Cholelithiasis
  • Cholesterol
  • Cholesterol, Dietary
  • Chromosome Mapping
  • Crosses, Genetic
  • Gallbladder
  • Genetic Markers
  • Genetic Predisposition to Disease
  • Male
  • Mice
  • Mice, Inbred AKR
  • Mice, Inbred C57BL
  • Organ Size
  • Quantitative Trait, Heritable
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Research

keywords

  • Abcb11
  • Abcc2
  • congenic
  • gallbladder
  • genetics
  • recombinant inbred strain
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Identity

International Standard Serial Number (ISSN)

  • 1094-8341

PubMed ID

  • 11074014
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Additional Document Info

start page

  • 59

end page

  • 65

volume

  • 4

issue

  • 1

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