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Dynamics of learning-related cAMP signaling and stimulus integration in the Drosophila olfactory pathway

Academic Article
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Overview

authors

  • Tomchik, Seth
  • Davis, Ronald

publication date

  • November 2009

journal

  • Neuron  Journal

abstract

  • Functional imaging with genetically encoded calcium and cAMP reporters was used to examine the signal integration underlying learning in Drosophila. Dopamine and octopamine modulated intracellular cAMP in spatially distinct patterns in mushroom body neurons. Pairing of neuronal depolarization with subsequent dopamine application revealed a synergistic increase in cAMP in the mushroom body lobes, which was dependent on the rutabaga adenylyl cyclase. This synergy was restricted to the axons of mushroom body neurons, and occurred only following forward pairing with time intervals similar to those required for behavioral conditioning. In contrast, forward pairing of neuronal depolarization and octopamine produced a subadditive effect on cAMP. Finally, elevating intracellular cAMP facilitated calcium transients in mushroom body neurons, suggesting that cAMP elevation is sufficient to induce presynaptic plasticity. These data suggest that rutabaga functions as a coincidence detector in an intact neuronal circuit, with dopamine and octopamine bidirectionally influencing the generation of cAMP.

subject areas

  • Animals
  • Cyclic AMP
  • Drosophila
  • Electric Stimulation
  • Learning
  • Mushroom Bodies
  • Odorants
  • Olfactory Pathways
  • Signal Transduction
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Identity

PubMed Central ID

  • PMC4080329

International Standard Serial Number (ISSN)

  • 0896-6273

Digital Object Identifier (DOI)

  • 10.1016/j.neuron.2009.09.029

PubMed ID

  • 19945393
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Additional Document Info

start page

  • 510

end page

  • 521

volume

  • 64

issue

  • 4

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