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Virus-specific cd8+ cytotoxic t-lymphocyte activity associated with control of viremia in primary human-immunodeficiency-virus type-1 infection

Academic Article
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Overview

authors

  • Borrow, P.
  • Lewicki, H.
  • Hahn, B. H.
  • Shaw, G. M.
  • Oldstone, Michael

publication date

  • September 1994

journal

  • Journal of Virology  Journal

abstract

  • Human immunodeficiency virus type 1 (HIV-1) Env-, Gag-, Pol-, Nef-, and Tat-specific cytotoxic T-lymphocyte (CTL) activities were quantitated temporally in five patients with symptomatic primary HIV-1 infection. A dominant CD8(+)-mediated, major histocompatibility complex class I-restricted CTL response to the HIV-1 envelope glycoprotein, gp160, was noted in four of the five patients studied. The level of HIV-1-specific CTL activity in the five patients paralleled the efficiency of control of primary viremia. Patients who mounted strong gp160-specific CTL responses showed rapid reduction of acute plasma viremia and antigenemia, while in contrast, primary viremia and antigenemia were poorly controlled in patients in whom virus-specific CTL activity was low or undetectable. These results suggest that HIV-1-specific CTL activity is a major component of the host immune response associated with the control of virus replication following primary HIV-1 infection and have important implications for the design of antiviral vaccines.

subject areas

  • Amino Acid Sequence
  • Gene Products, env
  • HIV Antigens
  • HIV Envelope Protein gp160
  • HIV Infections
  • HIV-1
  • Humans
  • Molecular Sequence Data
  • Peptides
  • Protein Precursors
  • T-Lymphocyte Subsets
  • T-Lymphocytes, Cytotoxic
  • Viremia
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Identity

PubMed Central ID

  • PMC237022

International Standard Serial Number (ISSN)

  • 0022-538X

PubMed ID

  • 8057491
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Additional Document Info

start page

  • 6103

end page

  • 6110

volume

  • 68

issue

  • 9

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