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Transformation of chicken cells by the gene encoding the catalytic subunit of pi 3-kinase

Academic Article
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Overview

authors

  • Chang, H. W.
  • Aoki, M.
  • Fruman, D.
  • Auger, K. R.
  • Bellacosa, A.
  • Tsichlis, P. N.
  • Cantley, L. C.
  • Roberts, T. M.
  • Vogt, Peter K.

publication date

  • June 1997

journal

  • Science  Journal

abstract

  • The avian sarcoma virus 16 (ASV 16) is a retrovirus that induces hemangiosarcomas in chickens. Analysis of the ASV 16 genome revealed that it encodes an oncogene that is derived from the cellular gene for the catalytic subunit of phosphoinositide 3-kinase (PI 3-kinase). The gene is referred to as v-p3k, and like its cellular counterpart c-p3k, it is a potent transforming gene in cultured chicken embryo fibroblasts (CEFs). The products of the viral and cellular p3k genes have PI 3-kinase activity. CEFs transformed with either gene showed elevated levels of phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate and activation of Akt kinase.

subject areas

  • Amino Acid Sequence
  • Animals
  • Avian Sarcoma Viruses
  • Cell Transformation, Neoplastic
  • Cell Transformation, Viral
  • Cells, Cultured
  • Chick Embryo
  • Chickens
  • Cloning, Molecular
  • Enzyme Activation
  • Genes, Viral
  • Hemangiosarcoma
  • Molecular Sequence Data
  • Oncogenes
  • Phosphatidylinositol 3-Kinases
  • Phosphatidylinositol Phosphates
  • Phosphotransferases (Alcohol Group Acceptor)
  • Platelet-Derived Growth Factor
  • Protein Serine-Threonine Kinases
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-akt
  • Signal Transduction
  • Transfection
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Identity

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.276.5320.1848

PubMed ID

  • 9188528
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Additional Document Info

start page

  • 1848

end page

  • 1850

volume

  • 276

issue

  • 5320

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