recent publications
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academic article
- Rader, C., Segal, D. J., Shabat, D. Carlos F. Barbas III (1964-2014): Visionary at the interface of chemistry and biology ACS Chemical Biology 2014 9:1645-1646 DOI:10.1021/cb5005993 PMID:25123302
- Segal, D. J., Crotty, J. W., Bhakta, M. S., Barbas, C. F., Horton, N. C. Structure of aart, a designed six-finger zinc finger peptide, bound to DNA Journal of Molecular Biology 2006 363:405-421 DOI:10.1016/j.jmb.2006.08.016 PMID:16963084
- Eberhardy, S. R., Goncalves, J., Coelho, S., Segal, D. J., Berkhout, B., Barbas, C. F. Inhibition of human immunodeficiency virus type 1 replication with artificial transcription factors targeting the highly conserved primer-binding site Journal of Virology 2006 80:2873-2883 DOI:10.1128/jvi.80.6.2873-2883.2006 PMID:16501096
- Dreier, B., Fuller, R. P., Segal, D. J., Lund, C. V., Blancafort, P., Huber, A., Koksch, B., Barbas, C. F. Development of zinc finger domains for recognition of the 5'-CNN-3' family DNA sequences and their use in the construction of artificial transcription factors Journal of Biological Chemistry 2005 280:35588-35597 DOI:10.1074/jbc.M506654200 PMID:16107335
- Crotty, J. W., Etzkorn, C., Barbas, C. F., 3rd, Segal, D. J., Horton, N. C. Crystallization and preliminary x-ray crystallographic analysis of aart, a designed six-finger zinc-finger peptide, bound to DNA Acta Crystallographica Section F-Structural Biology and Crystallization Communications 2005 61:573-576 DOI:10.1107/s1744309105014363 PMID:16511099 PMCID:PMC1952332
- Blancafort, P., Segal, D. J., Barbas, C. F. Designing transcription factor architectures for drug discovery Molecular Pharmacology 2004 66:1361-1371 DOI:10.1124/mol.104.002758. PMID:15340042
- Segal, D. J., Goncalves, J., Eberhardy, S., Swan, C. H., Torbett, B. E., Li, X. L., Barbas, C. F. Attenuation of HIV-1 replication in primary human cells with a designed zinc finger transcription factor Journal of Biological Chemistry 2004 279:14509-14519 DOI:10.1074/jbc.M400349200 PMID:14734553
- Tan, W. J., Zhu, K., Segal, D. J., Barbas, C. F., Chow, S. A. Fusion proteins consisting of human immunodeficiency virus type 1 integrase and the designed polydactyl zinc finger protein e2c direct integration of viral DNA into specific sites Journal of Virology 2004 78:1301-1313 DOI:10.1128/jvi.78.3.1301-1313.2004 PMID:14722285
- Segal, D. J., Stege, J. T., Barbas, C. F. Zinc fingers and a green thumb: Manipulating gene expression in plants Current Opinion in Plant Biology 2003 6:163-168 DOI:10.1016/s1369-5266(03)00007-4 PMID:12667874
- Segal, D. J., Beerli, R. R., Blancafort, P., Dreier, B., Effertz, K., Huber, A., Koksch, B., Lund, C. V., Magnenat, L., Valente, D., Barbas, C. F. Evaluation of a modular strategy for the construction of novel polydactyl zinc finger DNA-binding proteins Biochemistry 2003 42:2137-2148 DOI:10.1021/bi026806o PMID:12590603
- Segal, D. J., Barbas, C. F. Custom DNA-binding proteins come of age: Polydactyl zinc-finger proteins Current Opinion in Biotechnology 2001 12:632-637 DOI:10.1016/s0958-1669(01)00272-5 PMID:11849947
- Dreier, B., Beerli, R. R., Segal, D. J., Flippin, J. D., Barbas, C. F. Development of zinc finger domains for recognition of the 5 '-ann-3 ' family of DNA sequences and their use in the construction of artificial transcription factors Journal of Biological Chemistry 2001 276:29466-29478 DOI:10.1074/jbc.M102604200 PMID:11340073
- Dreier, B., Segal, D. J., Barbas, C. F. Insights into the molecular recognition of the 5 '-gnn-3 ' family of DNA sequences by zinc finger domains Journal of Molecular Biology 2000 303:489-502 DOI:10.1006/jmbi.2000.4133 PMID:11054286
- Segal, D. J., Barbas, C. F. Design of novel sequence-specific DNA-binding proteins Current Opinion in Chemical Biology 2000 4:34-39 DOI:10.1016/s1367-5931(99)00048-4 PMID:10679372
- Barbas, C. F., Rader, C., Segal, D. J., List, B., Turner, J. M. From catalytic asymmetric synthesis to the transcriptional regulation of genes: in vivo and in vitro evolution of proteins Advances in Protein Chemistry 2000 55:317-366 DOI:10.1016/S0065-3233(01)55008-1 PMID:11050938
- Segal, D. J., Dreier, B., Beerli, R. R., Barbas, C. F. Toward controlling gene expression at will: Selection and design of zinc finger domains recognizing each of the 5 '-gnn-3 ' DNA target sequences Proceedings of the National Academy of Sciences of the United States of America 1999 96:2758-2763 DOI:10.1073/pnas.96.6.2758 PMID:10077584
- Beerli, R. R., Segal, D. J., Dreier, B., Barbas, C. F. Toward controlling gene expression at will: Specific regulation of the erbb-2/her-2 promoter by using polydactyl zinc finger proteins constructed from modular building blocks Proceedings of the National Academy of Sciences of the United States of America 1998 95:14628-14633 DOI:10.1073/pnas.95.25.14628 PMID:9843940
- Liu, Q., Segal, D. J., Ghiara, J. B., Barbas, C. F. Design of polydactyl zinc-finger proteins for unique addressing within complex genomes Proceedings of the National Academy of Sciences of the United States of America 1997 94:5525-5530 DOI:10.1073/pnas.94.11.5525 PMID:9159105