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Targeted disruption of beta 1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction

Academic Article
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Overview

authors

  • White, D. E.
  • Kurpios, N. A.
  • Zuo, D. M.
  • Hassell, J. A.
  • Blaess, S.
  • Mueller, Ulrich
  • Muller, W. J.

publication date

  • August 2004

journal

  • Cancer Cell  Journal

abstract

  • Despite evidence demonstrating the role of beta1-integrin in the regulation of cancer cell proliferation in vitro, the importance of this cell adhesion receptor during the initiation and progression of epithelial tumors in vivo remains unclear. Here we have used the Cre/LoxP1 recombination system to disrupt beta1-integrin function in the mammary epithelium of a transgenic mouse model of human breast cancer. Using this approach, we show that beta1-integrin expression is critical for the initiation of mammary tumorigenesis in vivo, and for maintaining the proliferative capacity of late-stage tumor cells. These observations provide a direct demonstration that beta1-integrin plays a critical role in both the initiation and maintenance of mammary tumor growth in vivo.

subject areas

  • Animals
  • Antigens, CD29
  • Breast Neoplasms
  • Cell Division
  • Cell Transformation, Neoplastic
  • Female
  • Focal Adhesion Kinase 1
  • Focal Adhesion Protein-Tyrosine Kinases
  • Gene Targeting
  • Humans
  • Mammary Glands, Animal
  • Mice
  • Mice, Transgenic
  • Neoplasm Transplantation
  • Protein-Tyrosine Kinases
  • Tumor Cells, Cultured
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Identity

International Standard Serial Number (ISSN)

  • 1535-6108

Digital Object Identifier (DOI)

  • 10.1016/j.ccr.2004.06.025

PubMed ID

  • 15324699
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Additional Document Info

start page

  • 159

end page

  • 170

volume

  • 6

issue

  • 2

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