recent publications
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academic article
- Lee, J., Hayashi, M., Lo, J. F., Fearns, C., Chu, W. M., Luo, Y. P., Xiang, R., Chuang, T. H. Nuclear factor kappa B (NF-kappa B) activation primes cells to a pro-inflammatory polarized response to a Toll-like receptor 7 (TLR7) agonist Biochemical Journal 2009 421:301-310 DOI:10.1042/bj20090013 PMID:19426145 PMCID:PMC2746977
- Otsuka, M., Zheng, M., Hayashi, M., Lee, J. D., Yoshino, O., Lin, S., Han, J. Impaired microrna processing causes corpus luteum insufficiency and infertility in mice Journal of Clinical Investigation 2008 118:1944-1954 DOI:10.1172/jci33680 PMID:18398510 PMCID:PMC2289794
- Hayashi, M., Imanaka-Yoshida, K., Yoshida, T., Wood, M., Fearns, C., Tatake, R. J., Lee, J. D. A crucial role of mitochondrial Hsp40 in preventing dilated cardiomyopathy Nature Medicine 2006 12:128-132 DOI:10.1038/nm1327 PMID:16327803
- Hayashi, M., Fearns, C., Eliceiri, B., Yang, Y., Lee, J. D. Big mitogen-activated protein kinase 1/extracellular signal-regulated kinase 5 signaling pathway is essential for tumor-associated angiogenesis Cancer Research 2005 65:7699-7706 DOI:10.1158/0008-5472.can-04-4540 PMID:16140937
- Yamamoto, K., Kojima, T., Adachi, T., Hayashi, M., Matsushita, T., Takamatsu, J., Loskutoff, D. J., Saito, H. Obesity enhances the induction of plasminogen activator inhibitor-1 by restraint stress: a possible mechanism of stress-induced renal fibrin deposition in obese mice Journal of Thrombosis and Haemostasis 2005 3:1495-1502 DOI:10.1111/j.1538-7836.2005.01399.x PMID:15978107
- Kim, S. W., Hayashi, M., Lo, J. F., Fearns, C., Xiang, R., Lazennec, G., Yang, Y., Lee, J. D. Tid1 negatively regulates the migratory potential of cancer cells by inhibiting the production of interieukin-8 Cancer Research 2005 65:8784-8791 DOI:10.1158/0008-5472.can-04-4422 PMID:16204048
- Takeshita, K., Hayashi, M., Iino, S., Kondo, T., Inden, Y., Iwase, M., Kojima, T., Hirai, M., Ito, M., Loskutoff, D. J., Saito, H., Murohara, T., et al. Increased expression of plasminogen activator inhibitor-1 in cardiomyocytes contributes to cardiac fibrosis after myocardial infarction American Journal of Pathology 2004 164:449-456 DOI:10.1016/s0002-9440(10)63135-5 PMID:14742251 PMCID:PMC1602257
- Tapping, R. I., Yutaka, K., Chao, T. H., Hayashi, M., Lo, J. F., Kim, S. W., Lee, J. D. Investigating the cellular BMK1/ERK5 signaling pathway Methods in Molecular Biology 2004 250:89-96 DOI:10.1385/1-59259-671-1:89 PMID:14755081
- Hayashi, M., Lee, J. D. Role of the bmk1/erk5 signaling pathway: Lessons from knockout mice Journal of Molecular Medicine-JMM 2004 82:800-808 DOI:10.1007/s00109-004-0602-8 PMID:15517128
- Hayashi, M., Kim, S. W., Imanaka-Yoshida, K., Yoshida, T., Abel, E. D., Eliceiri, B., Yang, Y., Ulevitch, R. J., Lee, J. D. Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial failure Journal of Clinical Investigation 2004 113:1138-1148 DOI:10.1172/jci200419890 PMID:15085193 PMCID:PMC385403
- Lo, J. F., Hayashi, M., Woo-Kim, S., Tian, B., Huang, J. F., Fearns, C., Takayama, S., Zapata, J. M., Yang, Y., Lee, J. D. Tid1, a cochaperone of the heat shock 70 protein and the mammalian counterpart of the Drosophila tumor suppressor 1(2)tid, is critical for early embryonic development and cell survival Molecular and Cellular Biology 2004 24:2226-2236 DOI:10.1128/mcb.24.6.2226-2236.2004 PMID:14993262 PMCID:PMC355836
- Kim, S. W., Hayashi, M., Lo, J. F., Yang, Y., Yoo, J. S., Lee, J. D. Adp-ribosylation factor 4 small gtpase mediates epidermal growth factor receptor-dependent phospholipase d2 activation Journal of Biological Chemistry 2003 278:2661-2668 DOI:10.1074/jbc.M205819200 PMID:12446727
- Hayashi, M., Tapping, R. I., Chao, T. H., Lo, J. F., King, C. C., Yang, Y., Lee, J. D. Bmk1 mediates growth factor-induced cell proliferation through direct cellular activation of serum and glucocorticoid-inducible kinase Journal of Biological Chemistry 2001 276:8631-8634 DOI:10.1074/jbc.C000838200 PMID:11254654
- Kato, Y., Chao, T. H., Hayashi, M., Tapping, R. I., Lee, J. D. Role of bmk1 in regulation of growth factor-induced cellular responses Immunologic Research 2000 21:233-237 DOI:10.1385/ir:21:2-3:233 PMID:10852122
- Chao, T. H., Hayashi, M., Tapping, R. I., Kato, Y., Lee, J. D. Mekk3 directly regulates mek5 activity as part of the big mitogen-activated protein kinase 1 (bmk1) signaling pathway Journal of Biological Chemistry 1999 274:36035-36038 DOI:10.1074/jbc.274.51.36035 PMID:10593883
- Tojo, S. J., Yokota, S., Koike, H., Schultz, J., Hamazume, Y., Misugi, E., Yamada, K., Hayashi, M., Paulson, J. C., Morooka, S. Reduction of rat myocardial ischemia and reperfusion injury by sialyl lewis x oligosaccharide and anti-rat p-selectin antibodies Glycobiology 1996 6:463-469 DOI:10.1093/glycob/6.4.463 PMID:8842711
- Hayashi, M., Lu, L. D. L., Okamura, F., Toba, T., Oguni, N., Sharpless, K. B. Kinetic resolution of racemic beta-hydroxy amines by enantioselective n-oxide formation Chemistry Letters 1990 547-548 DOI:10.1246/cl.1990.547