Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Phenotypic and functional-analysis of gamma-delta-t-cell receptor-positive murine dendritic epidermal clones

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Havran, Wendy
  • Poenie, M.
  • Tigelaar, R. E.
  • Tsien, R. Y.
  • Allison, J. P.

publication date

  • March 1989

journal

  • Journal of Immunology  Journal

abstract

  • Thy-1+ dendritic cells isolated from the epidermis of normal mice (dEC)3 bear the gamma delta TCR associated with the CD3 complex. We have analyzed the effects of antibodies directed against the TCR complex, Ly-6C, and Thy-1, as well as pharmacologic agents which have been shown to activate T cells without engagement of the TCR complex, on levels of intracellular free calcium, activation of protein kinase C, cytolysis, IL-2R expression, and secretion of lymphokines by dEC clones. We have found that the dEC cells express a fully functional TCR complex which can function to transmit signals upon perturbation leading to an increase in IL-2R expression, release of lymphokines, and cytolytic activity. These results indicate that the gamma delta TCR+ dEC are capable of responding to activation signals in the same manner as mature alpha beta TCR+ cells and suggests that they may play a functional role in the skin.

subject areas

  • Animals
  • Antibodies, Monoclonal
  • Antibody-Dependent Cell Cytotoxicity
  • Clone Cells
  • Cricetinae
  • Dendritic Cells
  • Enzyme Activation
  • Epidermis
  • Interleukin-3
  • Mice
  • Mice, Inbred AKR
  • Phenotype
  • Protein Kinase C
  • Receptors, Antigen, T-Cell
  • Receptors, Interleukin-2
  • Signal Transduction
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0022-1767

PubMed ID

  • 2783942
scroll to property group menus

Additional Document Info

start page

  • 1422

end page

  • 1428

volume

  • 142

issue

  • 5

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support