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Cocaine antagonizes anxiolytic effects of ethanol

Academic Article
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Overview

authors

  • Astonjones, S.
  • Astonjones, G.
  • Koob, George

publication date

  • 1984

journal

  • Psychopharmacology  Journal

abstract

  • A Geller-Seifter paradigm for discerning anxiolytic and ataxic effects of drugs was used to study the interactions between low doses of ethanol and cocaine. Ethanol produced significant anxiolytic and ataxic effects at a dose of 1 g/kg. Cocaine at a dose as low as 10 mg/kg markedly antagonized the anxiolytic effect of ethanol, but simultaneously augmented ethanol's ataxic effects, as measured by response rates during a random-interval schedule. These results indicate that ethanol may interact to a significant degree with brain aminergic systems and that, contrary to popular dogma, stimulants may reverse some components of ethanol intoxication, but increase ethanol's debilitating motor effects.

subject areas

  • Animals
  • Anti-Anxiety Agents
  • Ataxia
  • Cocaine
  • Conflict (Psychology)
  • Ethanol
  • Male
  • Punishment
  • Rats
  • Rats, Inbred Strains
  • Reinforcement Schedule
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Identity

International Standard Serial Number (ISSN)

  • 0033-3158

Digital Object Identifier (DOI)

  • 10.1007/bf00432019

PubMed ID

  • 6149593
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Additional Document Info

start page

  • 28

end page

  • 31

volume

  • 84

issue

  • 1

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