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IL-2/anti-IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptor α subunit CD25

Academic Article
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Overview

related to degree

  • Martin, Christopher, Ph.D. in Biology, Scripps Research 2006 - 2013

authors

  • Letourneau, S.
  • van Leeuwen, E. M. M.
  • Krieg, C.
  • Martin, Christopher
  • Pantaleo, G.
  • Sprent, Jonathan
  • Surh, Charles
  • Boyman, O.

publication date

  • February 2010

journal

  • Proceedings of the National Academy of Sciences of the United States of America  Journal

abstract

  • IL-2 is crucial to T cell homeostasis, especially of CD4(+) T regulatory cells and memory CD8(+) cells, as evidenced by vigorous proliferation of these cells in vivo following injections of superagonist IL-2/anti-IL-2 antibody complexes. The mechanism of IL-2/anti-IL-2 antibody complexes is unknown owing to a lack of understanding of IL-2 homeostasis. We show that IL-2 receptor alpha (CD25) plays a crucial role in IL-2 homeostasis. Thus, prolongation of IL-2 half-life and blocking of CD25 using antibodies or CD25-deficient mice led in combination, but not alone, to vigorous IL-2-mediated T cell proliferation, similar to IL-2/anti-IL-2 antibody complexes. These data suggest an unpredicted role for CD25 in IL-2 homeostasis.

subject areas

  • Animals
  • Antibodies, Blocking
  • Antigen-Antibody Complex
  • Half-Life
  • Homeostasis
  • Immunoglobulin G
  • Interleukin-2
  • Interleukin-2 Receptor alpha Subunit
  • Mice
  • Mice, Congenic
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Mice, Transgenic
  • Receptors, Fc
  • Recombinant Fusion Proteins
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Research

keywords

  • CD25
  • Fc receptor
  • T cell homeostasis
  • cytokine
  • cytokine/mAb complexes
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Identity

PubMed Central ID

  • PMC2836659

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.0909384107

PubMed ID

  • 20133862
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Additional Document Info

start page

  • 2171

end page

  • 2176

volume

  • 107

issue

  • 5

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