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A thymic precursor to the NK T cell lineage

Academic Article
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Overview

authors

  • Benlagha, K.
  • Kyin, T.
  • Beavis, A.
  • Teyton, Luc
  • Bendelac, A.

publication date

  • April 2002

journal

  • Science  Journal

abstract

  • CD1d-restricted autoreactive natural killer (NK1.1+) T cells function as regulatory cells in various disease conditions. Using improved tetramer tracking methodology, we identified a NK1.1- thymic precursor and followed its differentiation and emigration to tissues by direct cell transfer and in situ cell labeling studies. A major lineage expansion occurred within the thymus after positive selection and before NK receptor expression. Surprisingly, cytokine analysis of the developmental intermediates between NK and NK+ stages showed a T helper cell TH2 to TH1 conversion, suggesting that the regulatory functions of NK T cells may be developmentally controlled. These findings characterize novel thymic and postthymic developmental pathways that expand autoreactive cells and differentiate them into regulatory cells.

subject areas

  • Animals
  • Antigens
  • Antigens, CD1
  • Antigens, CD1d
  • Antigens, CD44
  • Antigens, Ly
  • Antigens, Surface
  • Cell Differentiation
  • Cell Division
  • Cell Lineage
  • Interferon-gamma
  • Interleukins
  • Killer Cells, Natural
  • Lectins, C-Type
  • Liver
  • Lymphocyte Activation
  • Mice
  • NK Cell Lectin-Like Receptor Subfamily B
  • Proteins
  • Receptors, Antigen, T-Cell, alpha-beta
  • Receptors, Immunologic
  • Spleen
  • T-Lymphocyte Subsets
  • T-Lymphocytes, Helper-Inducer
  • Thymus Gland
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Identity

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.1069017

PubMed ID

  • 11968185
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Additional Document Info

start page

  • 553

end page

  • 555

volume

  • 296

issue

  • 5567

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