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Different antiplatelet antibody specificities in immune thrombocytopenic purpura

Academic Article
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Overview

authors

  • Donnell, R. L.
  • Mc Millan, Robert
  • Yelenosky, R. J.
  • Longmire, R. L.
  • Lightsey, A. L.

publication date

  • 1976

journal

  • British Journal of Haematology  Journal

abstract

  • It is generally accepted that patients with immune thrombocytopenic purpura (ITP) produce antibody against platelet-associated antigens; however, it is not known if these antiplatelet antibodies are directed towards the same or different antigenic sites. In the present studies, quantities of antiplatelet antibody from different ITP patients, sufficient to saturate platelet antigenic sites, were simultaneously incubated with normal platelets and the quantity of platelet-binding IgG (PBIgG) was determined. In each of the five comparisons made, the amount of PBIgG bound after incubation of normal platelets with saturating quantities of two ITP antibodies approximated to the sum of the PBIgG bound after incubation with the antibodies separately. These data suggest that the antiplatelet antibody from these ITP patients differed in antigenic specificity.

subject areas

  • Antibody Specificity
  • Blood Platelets
  • Cell Membrane
  • Epitopes
  • Female
  • Humans
  • Immunoglobulin G
  • Isoantibodies
  • Male
  • Purpura, Thrombocytopenic
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Identity

International Standard Serial Number (ISSN)

  • 0007-1048

Digital Object Identifier (DOI)

  • 10.1111/j.1365-2141.1976.tb00183.x

PubMed ID

  • 60122
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Additional Document Info

start page

  • 147

end page

  • 151

volume

  • 34

issue

  • 1

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