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Abnormalities of pulmonary vascular dynamics and inflammation in early progressive systemic-sclerosis

Academic Article
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Overview

authors

  • Furst, D. E.
  • Davis, J. A.
  • Clements, P. J.
  • Chopra, S. K.
  • Theofilopoulos, Argyrios
  • Chia, D.

publication date

  • 1981

journal

  • Arthritis and Rheumatism  Journal

abstract

  • Abnormalities of pulmonary function were studied in 10 patients with progressive systemic sclerosis (PSS) and 3 control subjects. All underwent 81M krypton lung scanning and total body gallium scanning. Immune complexes were measured by Raji cell radioimmunoassay and polyethylene glycol (PEG) assay. Perfusion scans were abnormal in 7 of 9 patients, and 5 of 9 showed a decrease in pulmonary perfusion after cold challenge. Increased gallium uptake was noted in the lungs of 6 of 9 patients. Krypton scans were normal in the control group. Elevated immune complexes were noted in 8 of 10 patients by the Raji assay and in 5 of 10 with the PEG assay. Efforts to separate patients with PSS into subgroups may lead to a better understanding of and advances in therapy for PSS.

subject areas

  • Adult
  • Aged
  • Antigen-Antibody Complex
  • Female
  • Gallium Radioisotopes
  • Humans
  • Krypton
  • Lung
  • Male
  • Middle Aged
  • Pulmonary Circulation
  • Radioisotopes
  • Scleroderma, Systemic
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Identity

International Standard Serial Number (ISSN)

  • 0004-3591

Digital Object Identifier (DOI)

  • 10.1002/art.1780241111

PubMed ID

  • 7317117
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Additional Document Info

start page

  • 1403

end page

  • 1408

volume

  • 24

issue

  • 11

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