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Cyclin-e controls s-phase progression and its down-regulation during drosophila embryogenesis is required for the arrest of cell-proliferation

Academic Article
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Overview

authors

  • Knoblich, J. A.
  • Sauer, Karsten
  • Jones, L.
  • Richardson, H.
  • Saint, R.
  • Lehner, C. F.

publication date

  • April 1994

journal

  • Cell  Journal

abstract

  • Most cells of the dorsal epidermis exit from the mitotic cycle after division 16 in Drosophila embryogenesis. This exit is dependent on the down-regulation of Drosophila cyclin E (DmcycE) during the final mitotic cycle. Ectopic expression of DmcycE after the final mitosis induces entry into S phase and reaccumulation of G2 cyclins and results in progression through a complete additional cell cycle. Conversely, analyses in DmcycE mutant embryos indicate that cyclin E is required for progression through S phase of the mitotic cycle. Moreover, endoreplication, which occurs in late wild-type embryos in the same pattern as DmcycE expression, is not observed in the mutant embryos. Therefore, Drosophila cyclin E, which forms a complex with the Dmcdc2c kinase, controls progression through S phase and its down-regulation limits embryonic proliferation.

subject areas

  • Animals
  • Base Sequence
  • CDC2 Protein Kinase
  • Cell Cycle
  • Cyclins
  • DNA Primers
  • Drosophila melanogaster
  • Gene Expression Regulation
  • Growth Inhibitors
  • Mitosis
  • Molecular Sequence Data
  • RNA, Messenger
  • S Phase
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Identity

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/0092-8674(94)90239-9

PubMed ID

  • 8156587
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Additional Document Info

start page

  • 107

end page

  • 120

volume

  • 77

issue

  • 1

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