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Decreased production of nitric oxide by human neutrophils during septic multiple organ dysfunction syndrome. Comparison with endotoxin and cytokine effects on normal cells

Academic Article
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Overview

authors

  • Carreras, M. C.
  • Catz, Sergio
  • Pargament, G. A.
  • Delbosco, C. G.
  • Poderoso, J. J.

publication date

  • April 1994

journal

  • Inflammation  Journal

abstract

  • The objective of this study was to determine nitric oxide (NO) and superoxide anion release (O-2) by neutrophils (PMNs) in the septic multiple organ dysfunction syndrome (MODS) and to compare them with the response of normal cells to lipopolysaccharide (LPS) and cytokines. NO production was measured by the release of nitrites in the medium, its maximal production rate by a modified oxyhemoglobin assay and O-2 by standard methods. Normal cells were incubated with LPS, gamma interferon (IFN-gamma), or tumor necrosis factor (TNF-alpha) alone or in combination. Results showed that PMN release of both NO and O-2 was reduced in septic samples; in contrast, an association of LPS, IFN-gamma, and TNF-alpha promoted maximal NO release by normal cells (40-50%). We conclude that while interaction of normal PMNs with cytokines increases NO and O-2 release, progression of sepsis to a multiple organ dysfunction impairs these responses in both functions.

subject areas

  • Adult
  • Aged
  • Anions
  • Bacterial Infections
  • Cytokines
  • Endotoxins
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neutrophils
  • Nitric Oxide
  • Oxygen Consumption
  • Superoxides
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Identity

International Standard Serial Number (ISSN)

  • 0360-3997

Digital Object Identifier (DOI)

  • 10.1007/bf01534556

PubMed ID

  • 8070900
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Additional Document Info

start page

  • 151

end page

  • 161

volume

  • 18

issue

  • 2

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