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Modeling AIDS in a mouse

Academic Article
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Overview

authors

  • Mosier, Donald

publication date

  • September 1996

journal

  • Hospital Practice  Journal

abstract

  • Mice that are lacking their own lymphocytes are given a human immune system, which then is infected with HIV. Such models are proving themselves in studies of immunization techniques. They also yield insights into HIV, including its capacity for infecting particular cell types and its so-called accessory genes. The models may even help in establishing precisely how HIV kills host CD4 T cells.

subject areas

  • Acquired Immunodeficiency Syndrome
  • Animals
  • Antigen-Presenting Cells
  • CD4-Positive T-Lymphocytes
  • Disease Models, Animal
  • Genes, nef
  • Genetic Variation
  • HIV-1
  • Humans
  • Immunotherapy
  • Mice
  • Mice, SCID
  • Virus Replication
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Identity

International Standard Serial Number (ISSN)

  • 2154-8331

PubMed ID

  • 8814120
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Additional Document Info

start page

  • 41

end page

  • 48, 53

volume

  • 31

issue

  • 9

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