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Developmental regulation of b lymphocyte immune tolerance compartmentalizes clonal selection from receptor selection

Academic Article
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Overview

authors

  • Melamed, D.
  • Benschop, R. J.
  • Cambier, J. C.
  • Nemazee, David

publication date

  • January 1998

journal

  • Cell  Journal

abstract

  • B lymphocyte development is a highly ordered process that involves immunoglobulin gene rearrangements, antigen receptor expression, and a learning process that minimizes the development of cells with reactivity to self tissue. Two distinct mechanisms for immune tolerance have been defined that operate during early bone marrow stages of B cell development: apoptosis, which eliminates clones of cells, and receptor editing, which spares the cells but genetically reprograms their autoreactive antigen receptors through nested immunoglobulin L chain gene rearrangements. We show here that sensitivity to antigen-induced apoptosis arises relatively late in B cell development and is preceded by a functionally distinct developmental stage capable of receptor editing. This regulation compartmentalizes clonal selection from receptor selection.

subject areas

  • Amino Acid Sequence
  • Animals
  • Apoptosis
  • Autoantigens
  • B-Lymphocytes
  • Bone Marrow Cells
  • Calcium
  • Cell Differentiation
  • Cells, Cultured
  • Clonal Deletion
  • DNA-Binding Proteins
  • Gene Rearrangement, B-Lymphocyte, Light Chain
  • Genes, bcl-2
  • H-2 Antigens
  • Immune Tolerance
  • Immunoglobulin D
  • Immunoglobulin M
  • Mice
  • Mice, Transgenic
  • Molecular Sequence Data
  • RNA, Messenger
  • Receptors, Antigen, B-Cell
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Identity

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/s0092-8674(00)80912-5

PubMed ID

  • 9458042
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Additional Document Info

start page

  • 173

end page

  • 182

volume

  • 92

issue

  • 2

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