recent publications

• academic article

  • McCoy, L. E., Falkowska, E., Doores, K. J., Le, K., Sok, D., van Gils, M. J., Euler, Z., Burger, J. A., Seaman, M. S., Sanders, R. W., Schuitemaker, H., Poignard, P., et al. Incomplete neutralization and deviation from sigmoidal neutralization curves for HIV broadly neutralizing monoclonal antibodies PLoS Pathogens  2015 11:e1005110  DOI:10.1371/journal.ppat.1005110  PMID:26267277  PMCID:PMC4534392
  • Hoffenberg, S., Powell, R., Carpov, A., Wagner, D., Wilson, A., Pond, S. K., Lindsay, R., Arendt, H., DeStefano, J., Phogat, S., Poignard, P., Fling, S. P., et al. Identification of an HIV-1 clade A envelope that exhibits broad antigenicity and neutralization sensitivity and elicits antibodies targeting three distinct epitopes Journal of Virology  2013 87:5372-5383  DOI:10.1128/jvi.02827-12  PMID:23468492  PMCID:PMC3648150
  • Narayan, K. M., Agrawal, N., Du, S. X., Muranaka, J. E., Bauer, K., Leaman, D. P., Phung, P., Limoli, K., Chen, H. L., Boenig, R. I., Wrin, T., Zwick, M. B., et al. Prime-boost immunization of rabbits with HIV-1 gp120 elicits potent neutralization activity against a primary viral isolate PLoS One  2013 8:e52732  DOI:10.1371/journal.pone.0052732  PMID:23326351  PMCID:PMC3541383
  • Falkowska, E., Ramos, A., Feng, Y., Zhou, T. Q., Moquin, S., Walker, L. M., Wu, X., Seaman, M. S., Wrin, T., Kwong, P. D., Wyatt, R. T., Mascola, J. R., et al. PGV04, an HIV-1 gp120 CD4 binding site antibody, is broad and potent in neutralization but does not induce conformational changes characteristic of CD4 Journal of Virology  2012 86:4394-4403  DOI:10.1128/jvi.06973-11  PMID:22345481  PMCID:PMC3318667
  • Walker, L. M., Huber, M., Doores, K. J., Falkowska, E., Pejchal, R., Julien, J. P., Wang, S. K., Ramos, A., Chan-Hui, P. Y., Moyle, M., Mitcham, J. L., Hammond, P. W., et al. Broad neutralization coverage of HIV by multiple highly potent antibodies Nature  2011 477:466-470  DOI:10.1038/nature10373  PMID:21849977  PMCID:PMC3393110
  • Du, S. X., Xu, L., Zhang, W. G., Tang, S., Boenig, R. I., Chen, H., Mariano, E. B., Zwick, M. B., Parren, Pwhi, Burton, D. R., Wrin, T., Petropoulos, C. J., et al. A directed molecular evolution approach to improved immunogenicity of the hiv-1 envelope glycoprotein PLoS One  2011 6:e20927  DOI:10.1371/journal.pone.0020927  PMID:21738594  PMCID:PMC3126809
  • Walker, L. M., Phogat, S. K., Chan-Hui, P. Y., Wagner, D., Phung, P., Goss, J. L., Wrin, T., Simek, M. D., Fling, S., Mitcham, J. L., Lehrman, J. K., Priddy, F. H., et al. Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target Science  2009 326:285-289  DOI:10.1126/science.1178746  PMID:19729618  PMCID:PMC3335270
  • Simek, M. D., Rida, W., Priddy, F. H., Pung, P., Carrow, E., Laufer, D. S., Lehrman, J. K., Boaz, M., Tarragona-Fiol, T., Miiro, G., Birungi, J., Pozniak, A., et al. Human immunodeficiency virus type 1 elite neutralizers: Individuals with broad and potent neutralizing activity identified by using a high-throughput neutralization assay together with an analytical selection algorithm Journal of Virology  2009 83:7337-7348  DOI:10.1128/jvi.00110-09  PMID:19439467  PMCID:PMC2704778
  • Pantophlet, R., Wrin, T., Cavacini, L. A., Robinson, J. E., Burton, D. R. Neutralizing activity of antibodies to the v3 loop region of hiv-1 gp120 relative to their epitope fine specificity Virology  2008 381:251-260  DOI:10.1016/j.virol.2008.08.032  PMID:18822440  PMCID:PMC2613967
  • Pantophlet, R., Aguilar-Sino, R. O., Wrin, T., Cavacini, L. A., Burton, D. R. Analysis of the neutralization breadth of the anti-v3 antibody f425-b4e8 and re-assessment of its epitope fine specificity by scanning mutagenesis Virology  2007 364:441-453  DOI:10.1016/j.virol.2007.03.007  PMID:17418361  PMCID:PMC1985947
  • Binley, J. A., Wrin, T., Korber, B., Zwick, M. B., Wang, M., Chappey, C., Stiegler, G., Kunert, R., Zolla-Pazner, S., Katinger, H., Petropoulos, C. J., Burton, D. R. Comprehensive cross-clade neutralization analysis of a panel of anti-human immunodeficiency virus type 1 monoclonal antibodies Journal of Virology  2004 78:13232-13252  DOI:10.1128/jvi.78.23.13232-13252.2004  PMID:15542675
  • Labrijn, A. F., Poignard, P., Raja, A., Zwick, M. B., Delgado, K., Franti, M., Binley, J., Vivona, V., Grundner, C., Huang, C. C., Venturi, M., Petropoulos, C. J., et al. Access of antibody molecules to the conserved coreceptor binding site on glycoprotein gpl120 is sterically restricted on primary human immunodeficiency virus type 1 Journal of Virology  2003 77:10557-10565  DOI:10.1128/jvi.77.19.10557-10565.2003  PMID:12970440