recent publications
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academic article
- McCoy, L. E., Falkowska, E., Doores, K. J., Le, K., Sok, D., van Gils, M. J., Euler, Z., Burger, J. A., Seaman, M. S., Sanders, R. W., Schuitemaker, H., Poignard, P., et al. Incomplete neutralization and deviation from sigmoidal neutralization curves for HIV broadly neutralizing monoclonal antibodies PLoS Pathogens 2015 11:e1005110 DOI:10.1371/journal.ppat.1005110 PMID:26267277 PMCID:PMC4534392
- Hoffenberg, S., Powell, R., Carpov, A., Wagner, D., Wilson, A., Pond, S. K., Lindsay, R., Arendt, H., DeStefano, J., Phogat, S., Poignard, P., Fling, S. P., et al. Identification of an HIV-1 clade A envelope that exhibits broad antigenicity and neutralization sensitivity and elicits antibodies targeting three distinct epitopes Journal of Virology 2013 87:5372-5383 DOI:10.1128/jvi.02827-12 PMID:23468492 PMCID:PMC3648150
- Narayan, K. M., Agrawal, N., Du, S. X., Muranaka, J. E., Bauer, K., Leaman, D. P., Phung, P., Limoli, K., Chen, H. L., Boenig, R. I., Wrin, T., Zwick, M. B., et al. Prime-boost immunization of rabbits with HIV-1 gp120 elicits potent neutralization activity against a primary viral isolate PLoS One 2013 8:e52732 DOI:10.1371/journal.pone.0052732 PMID:23326351 PMCID:PMC3541383
- Falkowska, E., Ramos, A., Feng, Y., Zhou, T. Q., Moquin, S., Walker, L. M., Wu, X., Seaman, M. S., Wrin, T., Kwong, P. D., Wyatt, R. T., Mascola, J. R., et al. PGV04, an HIV-1 gp120 CD4 binding site antibody, is broad and potent in neutralization but does not induce conformational changes characteristic of CD4 Journal of Virology 2012 86:4394-4403 DOI:10.1128/jvi.06973-11 PMID:22345481 PMCID:PMC3318667
- Walker, L. M., Huber, M., Doores, K. J., Falkowska, E., Pejchal, R., Julien, J. P., Wang, S. K., Ramos, A., Chan-Hui, P. Y., Moyle, M., Mitcham, J. L., Hammond, P. W., et al. Broad neutralization coverage of HIV by multiple highly potent antibodies Nature 2011 477:466-470 DOI:10.1038/nature10373 PMID:21849977 PMCID:PMC3393110
- Du, S. X., Xu, L., Zhang, W. G., Tang, S., Boenig, R. I., Chen, H., Mariano, E. B., Zwick, M. B., Parren, Pwhi, Burton, D. R., Wrin, T., Petropoulos, C. J., et al. A directed molecular evolution approach to improved immunogenicity of the hiv-1 envelope glycoprotein PLoS One 2011 6:e20927 DOI:10.1371/journal.pone.0020927 PMID:21738594 PMCID:PMC3126809
- Walker, L. M., Phogat, S. K., Chan-Hui, P. Y., Wagner, D., Phung, P., Goss, J. L., Wrin, T., Simek, M. D., Fling, S., Mitcham, J. L., Lehrman, J. K., Priddy, F. H., et al. Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target Science 2009 326:285-289 DOI:10.1126/science.1178746 PMID:19729618 PMCID:PMC3335270
- Simek, M. D., Rida, W., Priddy, F. H., Pung, P., Carrow, E., Laufer, D. S., Lehrman, J. K., Boaz, M., Tarragona-Fiol, T., Miiro, G., Birungi, J., Pozniak, A., et al. Human immunodeficiency virus type 1 elite neutralizers: Individuals with broad and potent neutralizing activity identified by using a high-throughput neutralization assay together with an analytical selection algorithm Journal of Virology 2009 83:7337-7348 DOI:10.1128/jvi.00110-09 PMID:19439467 PMCID:PMC2704778
- Pantophlet, R., Wrin, T., Cavacini, L. A., Robinson, J. E., Burton, D. R. Neutralizing activity of antibodies to the v3 loop region of hiv-1 gp120 relative to their epitope fine specificity Virology 2008 381:251-260 DOI:10.1016/j.virol.2008.08.032 PMID:18822440 PMCID:PMC2613967
- Pantophlet, R., Aguilar-Sino, R. O., Wrin, T., Cavacini, L. A., Burton, D. R. Analysis of the neutralization breadth of the anti-v3 antibody f425-b4e8 and re-assessment of its epitope fine specificity by scanning mutagenesis Virology 2007 364:441-453 DOI:10.1016/j.virol.2007.03.007 PMID:17418361 PMCID:PMC1985947
- Binley, J. A., Wrin, T., Korber, B., Zwick, M. B., Wang, M., Chappey, C., Stiegler, G., Kunert, R., Zolla-Pazner, S., Katinger, H., Petropoulos, C. J., Burton, D. R. Comprehensive cross-clade neutralization analysis of a panel of anti-human immunodeficiency virus type 1 monoclonal antibodies Journal of Virology 2004 78:13232-13252 DOI:10.1128/jvi.78.23.13232-13252.2004 PMID:15542675
- Labrijn, A. F., Poignard, P., Raja, A., Zwick, M. B., Delgado, K., Franti, M., Binley, J., Vivona, V., Grundner, C., Huang, C. C., Venturi, M., Petropoulos, C. J., et al. Access of antibody molecules to the conserved coreceptor binding site on glycoprotein gpl120 is sterically restricted on primary human immunodeficiency virus type 1 Journal of Virology 2003 77:10557-10565 DOI:10.1128/jvi.77.19.10557-10565.2003 PMID:12970440