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A genetic marker in the variable region of light chains of mouse immunoglobulins

Academic Article
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Overview

authors

  • Edelman, Gerald
  • Gottlieb, P. D.

publication date

  • 1970

journal

  • Proceedings of the National Academy of Sciences of the United States of America  Journal

abstract

  • A genetic variation was observed upon autoradiographic comparison of tryptic peptide maps of (14)C-labeled normal light chains from 17 different inbred strains of mice. The difference was found in strains AKR/J, C58/J, and RF/J. Chemical analyses showed that the differences were in a region of the amino acid sequence in the neighborhood of half-cystine I of the variable region of the light chain. Breeding experiments showed that the difference segregated in a classical Mendelian fashion.

subject areas

  • Amino Acids
  • Animals
  • Autoradiography
  • Carbon Isotopes
  • Centrifugation, Density Gradient
  • Electrophoresis
  • Genetic Variation
  • Immunochemistry
  • Immunogenetics
  • Immunoglobulin G
  • Immunoglobulins
  • Inbreeding
  • Mice
  • Peptides
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Identity

PubMed Central ID

  • PMC283336

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.67.3.1192

PubMed ID

  • 5274448
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Additional Document Info

start page

  • 1192

end page

  • 1199

volume

  • 67

issue

  • 3

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