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Plasma cells negatively regulate the follicular helper t cell program

Academic Article
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Overview

authors

  • Pelletier, N.
  • McHeyzer-Williams, L. J.
  • Wong, K. A.
  • Urich, E.
  • Fazilleau, N.
  • McHeyzer-Williams, Michael G.

publication date

  • December 2010

journal

  • Nature Immunology  Journal

abstract

  • B lymphocytes differentiate into antibody-secreting cells under the antigen-specific control of follicular helper T cells (T(FH) cells). Here we demonstrate that isotype-switched plasma cells expressed major histocompatibility complex (MHC) class II, the costimulatory molecules CD80 and CD86, and the intracellular machinery required for antigen presentation. Antigen-specific plasma cells accessed, processed and presented sufficient antigen in vivo to induce multiple helper T cell functions. Notably, antigen-primed plasma cells failed to induce interleukin 21 (IL-21) or the transcriptional repressor Bcl-6 in naive helper T cells and actively decreased these key molecules in antigen-activated T(FH) cells. Mice lacking plasma cells showed altered T(FH) cell activity, which provided evidence of this negative feedback loop. Hence, antigen presentation by plasma cells defines a previously unknown layer of cognate regulation that limits the antigen-specific T(FH) cell program that controls ongoing B cell immunity.

subject areas

  • Adaptive Immunity
  • Animals
  • Antigen Presentation
  • Cell Separation
  • Enzyme-Linked Immunospot Assay
  • Flow Cytometry
  • Immunologic Memory
  • Lymphocyte Activation
  • Mice
  • Mice, Inbred C57BL
  • Microscopy, Confocal
  • Plasma Cells
  • Reverse Transcriptase Polymerase Chain Reaction
  • T-Lymphocytes, Helper-Inducer
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Identity

PubMed Central ID

  • PMC3058870

International Standard Serial Number (ISSN)

  • 1529-2908

Digital Object Identifier (DOI)

  • 10.1038/ni.1954

PubMed ID

  • 21037578
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Additional Document Info

start page

  • 1110

end page

  • 1118

volume

  • 11

issue

  • 12

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