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Amino acid dependent formation of phosphate anhydrides in water mediated by carbonyl sulfide

Academic Article
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Overview

related to degree

  • Leman, Lucas, Ph.D. in Chemistry, Scripps Research 2001 - 2006

authors

  • Leman, Lucas
  • Orgel, L. E.
  • Ghadiri, M. Reza

publication date

  • January 2006

journal

  • Journal of the American Chemical Society  Journal

abstract

  • Carbonyl sulfide (COS), a component of volcanic gas emissions and interstellar gas clouds, is shown to be an efficient condensing agent in the context of phosphate chemistry in aqueous solutions. We report that high-energy aminoacyl-phosphate anhydrides and aminoacyl adenylates are generated in solutions containing amino acids, COS, and the corresponding phosphate molecule. We further show that the mixed anhydrides of amino acids and inorganic phosphate are phosphorylating agents, producing pyrophosphate in better than 30% yield in the presence of Ca2+ precipitates. The amino acid dependent activations of phosphate reported here, which occur in parallel with the production of peptides, suggest that these two reactions may have shared a common intermediate on the prebiotic Earth.

subject areas

  • Amino Acids
  • Anhydrides
  • Diphosphates
  • Exobiology
  • Peptides
  • Phosphorus Compounds
  • Sulfur Oxides
  • Water
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Identity

International Standard Serial Number (ISSN)

  • 0002-7863

Digital Object Identifier (DOI)

  • 10.1021/ja056036e

PubMed ID

  • 16390101
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Additional Document Info

start page

  • 20

end page

  • 21

volume

  • 128

issue

  • 1

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