recent publications

• academic article

  • Okano, A., James, R. C., Pierce, J. G., Xie, J., Boger, D. L. Silver(I)-promoted conversion of thioamides to amidines: divergent synthesis of a key series of vancomycin aglycon residue 4 amidines that clarify binding behavior to model ligands Journal of the American Chemical Society  2012 134:8790-8793  DOI:10.1021/ja302808p  PMID:22568755  PMCID:PMC3365631
  • James, R. C., Pierce, J. G., Okano, A., Xie, J., Boger, D. L. Redesign of glycopeptide antibiotics: back to the future ACS Chemical Biology  2012 7:797-804  DOI:10.1021/cb300007j  PMID:22330049  PMCID:PMC3356478
  • Xie, J., Okano, A., Pierce, J. G., James, R. C., Stamm, S., Crane, C. M., Boger, D. L. Total synthesis of [Psi[C(═S)NH]Tpg4]vancomycin aglycon, [Psi[C(═NH)NH]Tpg4]vancomycin aglycon, and related key compounds: reengineering vancomycin for dual D-Ala-D-Ala and D-Ala-D-Lac binding Journal of the American Chemical Society  2012 134:1284-1297  DOI:10.1021/ja209937s  PMID:22188323  PMCID:PMC3262083
  • Xie, J., Pierce, J. G., James, R. C., Okano, A., Boger, D. L. A redesigned vancomycin engineered for dual D-Ala-D-ala And D-Ala-D-Lac binding exhibits potent antimicrobial activity against vancomycin-resistant bacteria Journal of the American Chemical Society  2011 133:13946-13949  DOI:10.1021/ja207142h  PMID:21823662  PMCID:PMC3164945
  • Crane, C. M., Pierce, J. G., Leung, S. S. F., Tirado-Rives, J., Jorgensen, W. L., Boger, D. L. Synthesis and evaluation of selected key methyl ether derivatives of vancomycin aglycon Journal of Medicinal Chemistry  2010 53:7229-7235  DOI:10.1021/jm100946e  PMID:20853900  PMCID:PMC2981068