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A reversible reaction inside a self-assembled capsule

Academic Article
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Overview

authors

  • Iwasawa, T.
  • Mann, E.
  • Rebek Jr., Julius

publication date

  • July 2006

journal

  • Journal of the American Chemical Society  Journal

abstract

  • Reversible encapsulation allows the direct observation of the isolated molecules under ambient conditions, at equilibrium and in the liquid phase. Here we show that capsules can amplify and stabilize molecules that are present in only trace concentrations in solution. Evidence is given that reversible chemical reactions take place within the capsule. Stabilization of reaction intermediates is a characteristic property of enzymes and is widely regarded as an essential feature of catalytic activity. Reactive molecules can also be stabilized by encapsulation, a process that involves completely surrounding the reactive species within synthetic receptors. Here, we show that self-assembled capsules can isolate and stabilize molecules that are present in only trace amounts in solution. The system amplifies the concentrations of high-energy species with reduced entropies.

subject areas

  • Binding Sites
  • Macromolecular Substances
  • Models, Molecular
  • Molecular Structure
  • Stereoisomerism
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Identity

International Standard Serial Number (ISSN)

  • 0002-7863

Digital Object Identifier (DOI)

  • 10.1021/ja062768a

PubMed ID

  • 16848447
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Additional Document Info

start page

  • 9308

end page

  • 9309

volume

  • 128

issue

  • 29

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