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Mapping of the full length and the truncated interleukin-18 receptor alpha in the mouse brain

Academic Article
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Overview

authors

  • Alboni, S.
  • Cervia, D.
  • Ross, B.
  • Montanari, C.
  • Gonzalez, A. S.
  • Sanchez-Alavez, Manuel
  • Marcondes, Maria Cecilia
  • De Vries, D.
  • Sugama, S.
  • Brunello, N.
  • Blom, J.
  • Tascedda, F.
  • Conti, Bruno

publication date

  • September 2009

journal

  • Journal of Neuroimmunology  Journal

abstract

  • The cytokine IL-18 acts on the CNS both in physiological and pathological conditions. Its action occurs through the heterodimeric receptor IL-18Ralpha\beta. To better understand IL-18 central effects, we investigated in the mouse brain the distribution of two IL-18Ralpha transcripts, a full length and an isoform lacking the intracellular domain hypothesized to be a decoy receptor. Both isoforms were expressed in neurons throughout the brain primarily with overlapping distribution but also with some unique pattern. These data suggest that IL-18 may modulate neuronal functions and that its action may be regulated through expression of a decoy receptor.

subject areas

  • Alternative Splicing
  • Animals
  • Brain
  • Cerebellum
  • Cerebral Cortex
  • Exons
  • Hippocampus
  • Hypothalamus
  • Immunohistochemistry
  • In Situ Hybridization
  • Interleukin-18
  • Interleukin-18 Receptor alpha Subunit
  • Interleukin-18 Receptor beta Subunit
  • Introns
  • Mice
  • Mice, Inbred C57BL
  • Protein Isoforms
  • Reverse Transcriptase Polymerase Chain Reaction
  • Transcription, Genetic
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Research

keywords

  • Brain
  • IL-18
  • IL-18R
  • Interleukin
  • Isoform
  • Receptor
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Identity

PubMed Central ID

  • PMC2745497

International Standard Serial Number (ISSN)

  • 0165-5728

Digital Object Identifier (DOI)

  • 10.1016/j.jneuroim.2009.06.016

PubMed ID

  • 19640592
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Additional Document Info

start page

  • 43

end page

  • 54

volume

  • 214

issue

  • 1-2

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