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Advances in thrombolytic therapy for acute myocardial-infarction

Academic Article
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Overview

authors

  • Topol, Eric

publication date

  • October 1987

journal

  • Journal of Clinical Pharmacology  Journal

abstract

  • There has been rapid proliferation of understanding and experience with thrombolytic therapy for acute myocardial infarction. Over the last few years, selective intracoronary infusion of lytic therapy has been replaced by intravenous administration because of the fundamental importance of time to reperfusion. Newer thrombolytic agents, such as tissue plasminogen activator (t-PA) and acylated streptokinase (APSAC), with properties distinct from streptokinase (SK) and urokinase, have been developed and have undergone extensive clinical trial evaluation. This review will focus primarily on the recent advances in thrombolytic therapy, with particular attention to efficacy, safety, and comparative aspects of the various agents currently or soon to be available.

subject areas

  • Clinical Trials as Topic
  • Fibrinolytic Agents
  • Humans
  • Myocardial Infarction
  • Recombinant Proteins
  • Streptokinase
  • Tissue Plasminogen Activator
  • United States
  • United States Food and Drug Administration
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Identity

International Standard Serial Number (ISSN)

  • 0091-2700

PubMed ID

  • 3123526
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Additional Document Info

start page

  • 735

end page

  • 745

volume

  • 27

issue

  • 10

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