recent publications

• academic article

  • Zhou, T., Lynch, R. M., Chen, L., Acharya, P., Wu, X., Doria-Rose, N. A., Joyce, M. G., Lingwood, D., Soto, C., Bailer, R. T., Ernandes, M. J., Kong, R., et al. Structural repertoire of HIV-1-neutralizing antibodies targeting the CD4 supersite in 14 donors Cell  2015 161:1280-1292  DOI:10.1016/j.cell.2015.05.007  PMID:26004070  PMCID:PMC4683157
  • Doria-Rose, N. A., Schramm, C. A., Gorman, J., Moore, P. L., Bhiman, J. N., DeKosky, B. J., Ernandes, M. J., Georgiev, I. S., Kim, H. J., Pancera, M., Staupe, R. P., Altae-Tran, H. R., et al. Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies Nature  2014 509:55-62  DOI:10.1038/nature13036  PMID:24590074  PMCID:PMC4395007
  • Zhou, T., Zhu, J., Wu, X., Moquin, S., Zhang, B., Acharya, P., Georgiev, I. S., Altae-Tran, H. R., Chuang, G. Y., Joyce, M. G., Kwon, Y. D., Longo, N. S., et al. Multidonor analysis reveals structural elements, genetic determinants, and maturation pathway for HIV-1 neutralization by VRC01-class antibodies Immunity  2013 39:245-258  DOI:10.1016/j.immuni.2013.04.012  PMID:23911655  PMCID:PMC3985390
  • Pancera, M., Shahzad-ul-Hussan, S., Doria-Rose, N. A., McLellan, J. S., Bailer, R. T., Dai, K., Loesgen, S., Louder, M. K., Staupe, R. P., Yang, Y., Zhang, B., Parks, R., et al. Structural basis for diverse N-glycan recognition by HIV-1-neutralizing V1-V2-directed antibody PG16 Nature Structural & Molecular Biology  2013 20:804-813  DOI:10.1038/nsmb.2600  PMID:23708607  PMCID:PMC4046252
  • Liao, H. X., Lynch, R., Zhou, T., Gao, F., Alam, S. M., Boyd, S. D., Fire, A. Z., Roskin, K. M., Schramm, C. A., Zhang, Z., Zhu, J., Shapiro, L., et al. Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus Nature  2013 496:469-476  DOI:10.1038/nature12053  PMID:23552890  PMCID:PMC3637846
  • Zhu, J., Ofek, G., Yang, Y. P., Zhang, B. S., Louder, M. K., Lu, G., McKee, K., Pancera, M., Skinner, J., Zhang, Z. H., Parks, R., Eudailey, J., et al. Mining the antibodyome for HIV-1-neutralizing antibodies with next-generation sequencing and phylogenetic pairing of heavy/light chains Proceedings of the National Academy of Sciences of the United States of America  2013 110:6470-6475  DOI:10.1073/pnas.1219320110  PMID:23536288  PMCID:PMC3631616
  • Pancera, M., Yang, Y. P., Louder, M. K., Gorman, J., Lu, G., McLellan, J. S., Stuckey, J., Zhu, J., Burton, D. R., Koff, W. C., Mascola, J. R., Kwong, P. D. N332-directed broadly neutralizing antibodies use diverse modes of HIV-1 recognition: inferences from heavy-light chain complementation of function PLoS One  2013 8:e55701  DOI:10.1371/journal.pone.0055701  PMID:23431362  PMCID:PMC3576407
  • Huang, J. H., Ofek, G., Laub, L., Louder, M. K., Doria-Rose, N. A., Longo, N. S., Imamichi, H., Bailer, R. T., Chakrabarti, B., Sharma, S. K., Alam, S. M., Wang, T., et al. Broad and potent neutralization of hiv-1 by a gp41-specific human antibody Nature  2012 491:406-12  DOI:10.1038/nature11544  PMID:23151583  PMCID:PMC4854285
  • Li, Y. X., O'Dell, S., Wilson, R., Wu, X., Schmidt, S. D., Hogerkorp, C. M., Louder, M. K., Longo, N. S., Poulsen, C., Guenaga, J., Chakrabarti, B. K., Doria-Rose, N., et al. Hiv-1 neutralizing antibodies display dual recognition of the primary and coreceptor binding sites and preferential binding to fully cleaved envelope glycoproteins Journal of Virology  2012 86:11231-11241  DOI:10.1128/jvi.01543-12  PMID:22875963  PMCID:PMC3457177
  • McLellan, J. S., Pancera, M., Carrico, C., Gorman, J., Julien, J. P., Khayat, R., Louder, R., Pejchal, R., Sastry, M., Dai, K. F., O'Dell, S., Patel, N., et al. Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9 Nature  2011 480:336-343  DOI:10.1038/nature10696  PMID:22113616  PMCID:PMC3406929
  • Li, Y. X., O'Dell, S., Walker, L. M., Wu, X. L., Guenaga, J., Feng, Y., Schmidt, S. D., McKee, K., Louder, M. K., Ledgerwood, J. E., Graham, B. S., Haynes, B. F., et al. Mechanism of neutralization by the broadly neutralizing HIV-1 monoclonal antibody VRC01 Journal of Virology  2011 85:8954-8967  DOI:10.1128/jvi.00754-11  PMID:21715490  PMCID:PMC3165784
  • Wu, X. L., Yang, Z. Y., Li, Y. X., Hogerkorp, C. M., Schief, W. R., Seaman, M. S., Zhou, T. Q., Schmidt, S. D., Wu, L., Xu, L., Longo, N. S., McKee, K., et al. Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to hiv-1 Science  2010 329:856-861  DOI:10.1126/science.1187659  PMID:20616233  PMCID:PMC2965066
  • Wu, L., Zhou, T. Q., Yang, Z. Y., Svehla, K., O'Dell, S., Louder, M. K., Xu, L., Mascola, J. R., Burton, D. R., Hoxie, J. A., Doms, R. W., Kwong, P. D., et al. Enhanced exposure of the cd4-binding site to neutralizing antibodies by structural design of a membrane-anchored human immunodeficiency virus type 1 gp120 domain Journal of Virology  2009 83:5077-5086  DOI:10.1128/jvi.02600-08  PMID:19264769  PMCID:PMC2682083
  • Li, Y. X., Svehla, K., Louder, M. K., Wycuff, D., Phogat, S., Tang, M., Migueles, S. A., Wu, X. L., Phogat, A., Shaw, G. M., Connors, M., Hoxie, J., et al. Analysis of neutralization specificities in polyclonal sera derived from human immunodeficiency virus type 1-infected individuals Journal of Virology  2009 83:1045-1059  DOI:10.1128/jvi.01992-08  PMID:19004942  PMCID:PMC2612402
  • Li, Y. X., Migueles, S. A., Welcher, B., Svehla, K., Phogat, A., Louder, M. K., Wu, X. L., Shaw, G. M., Connors, M., Wyatt, R. T., Mascola, J. R. Broad hiv-1 neutralization mediated by cd4-binding site antibodies Nature Medicine  2007 13:1032-1034  DOI:10.1038/nm1624  PMID:17721546  PMCID:PMC2584972
  • Kim, J. O., Chakrabarti, B. K., Guha-Niyogi, A., Louder, M. K., Mascola, J. R., Ganesh, L., Nabel, G. J. Lysis of human immunodeficiency virus type 1 by a specific secreted human phospholipase a(2) Journal of Virology  2007 81:1444-1450  DOI:10.1128/jvi.01790-06  PMID:17093191
  • Chakrabarti, B. K., Ling, X., Yang, Z. Y., Montefiori, D. C., Panet, A., Kong, W. P., Welcher, B., Louder, M. K., Mascola, J. R., Nabel, G. J. Expanded breadth of virus neutralization after immunization with a multiclade envelope hiv vaccine candidate Vaccine  2005 23:3434-3445  DOI:10.1016/j.vaccine.2005.01.099  PMID:15837367
  • Mascola, J. R., Sambor, A., Beaudry, K., Santra, S., Welcher, B., Louder, M. K., VanCott, T. C., Huang, Y., Chakrabarti, B. K., Kong, W. P., Yang, Z. Y., Xu, L., et al. Neutralizing antibodies elicited by immunization of monkeys with DNA plasmids and recombinant adenoviral vectors expressing human immunodeficiency virus type 1 proteins Journal of Virology  2005 79:771-779  DOI:10.1128/jvi.79.2.771-779.2005  PMID:15613305
  • Frankel, S. S., Steinman, R. M., Michael, N. L., Kim, S. R., Bhardwaj, N., Pope, M., Louder, M. K., Ehrenberg, P. K., Parren, Pwhi, Burton, D. R., Katinger, H., VanCott, T. C., et al. Neutralizing monoclonal antibodies block human immunodeficiency virus type 1 infection of dendritic cells and transmission to t cells Journal of Virology  1998 72:9788-9794  PMID:9811714  PMCID:PMC110490