recent publications
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academic article
- Zhou, T., Lynch, R. M., Chen, L., Acharya, P., Wu, X., Doria-Rose, N. A., Joyce, M. G., Lingwood, D., Soto, C., Bailer, R. T., Ernandes, M. J., Kong, R., et al. Structural repertoire of HIV-1-neutralizing antibodies targeting the CD4 supersite in 14 donors Cell 2015 161:1280-1292 DOI:10.1016/j.cell.2015.05.007 PMID:26004070 PMCID:PMC4683157
- Doria-Rose, N. A., Schramm, C. A., Gorman, J., Moore, P. L., Bhiman, J. N., DeKosky, B. J., Ernandes, M. J., Georgiev, I. S., Kim, H. J., Pancera, M., Staupe, R. P., Altae-Tran, H. R., et al. Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies Nature 2014 509:55-62 DOI:10.1038/nature13036 PMID:24590074 PMCID:PMC4395007
- Zhou, T., Zhu, J., Wu, X., Moquin, S., Zhang, B., Acharya, P., Georgiev, I. S., Altae-Tran, H. R., Chuang, G. Y., Joyce, M. G., Kwon, Y. D., Longo, N. S., et al. Multidonor analysis reveals structural elements, genetic determinants, and maturation pathway for HIV-1 neutralization by VRC01-class antibodies Immunity 2013 39:245-258 DOI:10.1016/j.immuni.2013.04.012 PMID:23911655 PMCID:PMC3985390
- Pancera, M., Shahzad-ul-Hussan, S., Doria-Rose, N. A., McLellan, J. S., Bailer, R. T., Dai, K., Loesgen, S., Louder, M. K., Staupe, R. P., Yang, Y., Zhang, B., Parks, R., et al. Structural basis for diverse N-glycan recognition by HIV-1-neutralizing V1-V2-directed antibody PG16 Nature Structural & Molecular Biology 2013 20:804-813 DOI:10.1038/nsmb.2600 PMID:23708607 PMCID:PMC4046252
- Liao, H. X., Lynch, R., Zhou, T., Gao, F., Alam, S. M., Boyd, S. D., Fire, A. Z., Roskin, K. M., Schramm, C. A., Zhang, Z., Zhu, J., Shapiro, L., et al. Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus Nature 2013 496:469-476 DOI:10.1038/nature12053 PMID:23552890 PMCID:PMC3637846
- Zhu, J., Ofek, G., Yang, Y. P., Zhang, B. S., Louder, M. K., Lu, G., McKee, K., Pancera, M., Skinner, J., Zhang, Z. H., Parks, R., Eudailey, J., et al. Mining the antibodyome for HIV-1-neutralizing antibodies with next-generation sequencing and phylogenetic pairing of heavy/light chains Proceedings of the National Academy of Sciences of the United States of America 2013 110:6470-6475 DOI:10.1073/pnas.1219320110 PMID:23536288 PMCID:PMC3631616
- Pancera, M., Yang, Y. P., Louder, M. K., Gorman, J., Lu, G., McLellan, J. S., Stuckey, J., Zhu, J., Burton, D. R., Koff, W. C., Mascola, J. R., Kwong, P. D. N332-directed broadly neutralizing antibodies use diverse modes of HIV-1 recognition: inferences from heavy-light chain complementation of function PLoS One 2013 8:e55701 DOI:10.1371/journal.pone.0055701 PMID:23431362 PMCID:PMC3576407
- Huang, J. H., Ofek, G., Laub, L., Louder, M. K., Doria-Rose, N. A., Longo, N. S., Imamichi, H., Bailer, R. T., Chakrabarti, B., Sharma, S. K., Alam, S. M., Wang, T., et al. Broad and potent neutralization of hiv-1 by a gp41-specific human antibody Nature 2012 491:406-12 DOI:10.1038/nature11544 PMID:23151583 PMCID:PMC4854285
- Li, Y. X., O'Dell, S., Wilson, R., Wu, X., Schmidt, S. D., Hogerkorp, C. M., Louder, M. K., Longo, N. S., Poulsen, C., Guenaga, J., Chakrabarti, B. K., Doria-Rose, N., et al. Hiv-1 neutralizing antibodies display dual recognition of the primary and coreceptor binding sites and preferential binding to fully cleaved envelope glycoproteins Journal of Virology 2012 86:11231-11241 DOI:10.1128/jvi.01543-12 PMID:22875963 PMCID:PMC3457177
- McLellan, J. S., Pancera, M., Carrico, C., Gorman, J., Julien, J. P., Khayat, R., Louder, R., Pejchal, R., Sastry, M., Dai, K. F., O'Dell, S., Patel, N., et al. Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9 Nature 2011 480:336-343 DOI:10.1038/nature10696 PMID:22113616 PMCID:PMC3406929
- Li, Y. X., O'Dell, S., Walker, L. M., Wu, X. L., Guenaga, J., Feng, Y., Schmidt, S. D., McKee, K., Louder, M. K., Ledgerwood, J. E., Graham, B. S., Haynes, B. F., et al. Mechanism of neutralization by the broadly neutralizing HIV-1 monoclonal antibody VRC01 Journal of Virology 2011 85:8954-8967 DOI:10.1128/jvi.00754-11 PMID:21715490 PMCID:PMC3165784
- Wu, X. L., Yang, Z. Y., Li, Y. X., Hogerkorp, C. M., Schief, W. R., Seaman, M. S., Zhou, T. Q., Schmidt, S. D., Wu, L., Xu, L., Longo, N. S., McKee, K., et al. Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to hiv-1 Science 2010 329:856-861 DOI:10.1126/science.1187659 PMID:20616233 PMCID:PMC2965066
- Wu, L., Zhou, T. Q., Yang, Z. Y., Svehla, K., O'Dell, S., Louder, M. K., Xu, L., Mascola, J. R., Burton, D. R., Hoxie, J. A., Doms, R. W., Kwong, P. D., et al. Enhanced exposure of the cd4-binding site to neutralizing antibodies by structural design of a membrane-anchored human immunodeficiency virus type 1 gp120 domain Journal of Virology 2009 83:5077-5086 DOI:10.1128/jvi.02600-08 PMID:19264769 PMCID:PMC2682083
- Li, Y. X., Svehla, K., Louder, M. K., Wycuff, D., Phogat, S., Tang, M., Migueles, S. A., Wu, X. L., Phogat, A., Shaw, G. M., Connors, M., Hoxie, J., et al. Analysis of neutralization specificities in polyclonal sera derived from human immunodeficiency virus type 1-infected individuals Journal of Virology 2009 83:1045-1059 DOI:10.1128/jvi.01992-08 PMID:19004942 PMCID:PMC2612402
- Li, Y. X., Migueles, S. A., Welcher, B., Svehla, K., Phogat, A., Louder, M. K., Wu, X. L., Shaw, G. M., Connors, M., Wyatt, R. T., Mascola, J. R. Broad hiv-1 neutralization mediated by cd4-binding site antibodies Nature Medicine 2007 13:1032-1034 DOI:10.1038/nm1624 PMID:17721546 PMCID:PMC2584972
- Kim, J. O., Chakrabarti, B. K., Guha-Niyogi, A., Louder, M. K., Mascola, J. R., Ganesh, L., Nabel, G. J. Lysis of human immunodeficiency virus type 1 by a specific secreted human phospholipase a(2) Journal of Virology 2007 81:1444-1450 DOI:10.1128/jvi.01790-06 PMID:17093191
- Chakrabarti, B. K., Ling, X., Yang, Z. Y., Montefiori, D. C., Panet, A., Kong, W. P., Welcher, B., Louder, M. K., Mascola, J. R., Nabel, G. J. Expanded breadth of virus neutralization after immunization with a multiclade envelope hiv vaccine candidate Vaccine 2005 23:3434-3445 DOI:10.1016/j.vaccine.2005.01.099 PMID:15837367
- Mascola, J. R., Sambor, A., Beaudry, K., Santra, S., Welcher, B., Louder, M. K., VanCott, T. C., Huang, Y., Chakrabarti, B. K., Kong, W. P., Yang, Z. Y., Xu, L., et al. Neutralizing antibodies elicited by immunization of monkeys with DNA plasmids and recombinant adenoviral vectors expressing human immunodeficiency virus type 1 proteins Journal of Virology 2005 79:771-779 DOI:10.1128/jvi.79.2.771-779.2005 PMID:15613305
- Frankel, S. S., Steinman, R. M., Michael, N. L., Kim, S. R., Bhardwaj, N., Pope, M., Louder, M. K., Ehrenberg, P. K., Parren, Pwhi, Burton, D. R., Katinger, H., VanCott, T. C., et al. Neutralizing monoclonal antibodies block human immunodeficiency virus type 1 infection of dendritic cells and transmission to t cells Journal of Virology 1998 72:9788-9794 PMID:9811714 PMCID:PMC110490