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Molecular cloning and chromosomal localization of the human cyclin c (ccnc) and cyclin e (ccne) genes: Deletion of the ccnc gene in human tumors

Academic Article
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Overview

authors

  • Li, H. M.
  • Lahti, J. M.
  • Valentine, M.
  • Saito, M.
  • Reed, Steven
  • Look, A. T.
  • Kidd, V. J.

publication date

  • March 1996

journal

  • Genomics  Journal

abstract

  • The human Gi-phase cyclins are important regulators of cell cycle progression that interact with various cyclin-dependent kinases and facilitate entry into S-phase. We have confirmed the localization of the human cyclin C (CCNC) gene to chromosome 6q21 and of human cyclin E (CCNE) to 19q12. The CCNC gene structure was also determined, and we have shown that it is deleted in a subset of acute lymphoblastic leukemias, including a patient sample containing a t(2;6)(p21;q15), with no apparent cytogenetic deletion. Single-strand conformational polymorphism analysis of the remaining CCNC allele from patients with a deletion of one allele established that there were no further mutations within the exons or the flanking intronic sequences. These results suggest either that haploinsufficiency of the cyclin C protein is sufficient to promote tumorigenesis or that the important tumor suppressor gene is linked to the CCNC locus.

subject areas

  • Chromosome Mapping
  • Chromosomes, Human, Pair 19
  • Chromosomes, Human, Pair 6
  • Cloning, Molecular
  • Cyclin C
  • Cyclins
  • Gene Deletion
  • Humans
  • Molecular Sequence Data
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
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Identity

International Standard Serial Number (ISSN)

  • 0888-7543

Digital Object Identifier (DOI)

  • 10.1006/geno.1996.0112

PubMed ID

  • 8833152
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Additional Document Info

start page

  • 253

end page

  • 259

volume

  • 32

issue

  • 2

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