related to degree

• Xu, Yang, Ph.D. in Chemistry, Scripps Research 2001 - 2007

authors

• Xu, Yang
• Yamamoto, N.
• Janda, Kim

publication date

• 2004

journal

• Bioorganic & Medicinal Chemistry  Journal

abstract

• Catalytic antibodies have emerged as powerful tools for the efficient and specific catalysis of a wide range of chemical transformations. Generating antibody catalysts that achieve enzymatic efficiency remains a challenging task, which has long been the source of great interest both in the design of more effective haptens for immunization and in the development of more direct and efficient screening methods for the selection of antibodies with desired catalytic capacities. In this review, we describe the development of different hapten design strategies, including a transition state analog (TSA) approach, 'bait-and-switch' catalysis, and reactive immunization. We also comment on recent developments in the screening process that allow for a more efficient identification of antibody catalysts.

subject areas

• Antibodies, Catalytic
• Drug Design
• Enzyme-Linked Immunosorbent Assay
• Haptens

International Standard Serial Number (ISSN)

• 0968-0896

Digital Object Identifier (DOI)

• 10.1016/j.bmc.2004.03.077

PubMed ID

• 15388154

start page

• 5247

end page

• 5268

volume

• 12

issue

• 20