recent publications

• academic article

  • Schoch, G. A., Yano, J. K., Sansen, S., Dansette, P. M., Stout, C. D., Johnson, E. F. Determinants of cytochrome P4502C8 substrate binding - structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid Journal of Biological Chemistry  2008 283:17227-17237  DOI:10.1074/jbc.M802180200  PMID:18413310  PMCID:PMC2427337
  • Sansen, S., Yano, J. K., Reynald, R. L., Schoch, G. A., Griffin, K. J., Stout, C. D., Johnson, E. F. Adaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human P450 1A2 Journal of Biological Chemistry  2007 282:14348-14355  DOI:10.1074/jbc.M611692200  PMID:17311915
  • Melet, A., Marques-Soares, C., Schoch, G. A., Macherey, A. C., Jaouen, M., Dansette, P. M., Sari, M. A., Johnson, E. F., Mansuy, D. Analysis of human cytochrome P4502C8 substrate specificity using a substrate pharmacophore and site-directed mutants Biochemistry  2004 43:15379-15392  DOI:10.1021/bi0489309  PMID:15581350
  • Schoch, G. A., Yano, J. K., Wester, M. R., Griffin, K. J., Stout, C. D., Johnson, E. F. Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site Journal of Biological Chemistry  2004 279:9497-9503  DOI:10.1074/jbc.M312516200  PMID:14676196
  • Wester, M. R., Yano, J. K., Schoch, G. A., Yang, C., Griffin, K. J., Stout, C. D., Johnson, E. F. The structure of human cytochrome P450 2C9 complexed with flurbiprofen at 2.0 Å resolution Journal of Biological Chemistry  2004 279:35630-35637  DOI:10.1074/jbc.M405427200  PMID:15181000
  • Yano, J. K., Wester, M. R., Schoch, G. A., Griffin, K. J., Stout, C. D., Johnson, E. F. The structure of human microsomal cytochrome P450 3A4 determined by X-ray crystallography to 2.05 Å resolution Journal of Biological Chemistry  2004 279:38091-38094  DOI:10.1074/jbc.C400293200  PMID:15258162