recent publications
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academic article
- Hutt, D. M., Olsen, C. A., Vickers, C. J., Herman, D., Chalfant, M. A., Montero, A., Leman, L. J., Burkle, R., Maryanoff, B. E., Balch, W. E., Ghadiri, M. R. Potential agents for treating cystic fibrosis: cyclic tetrapeptides that restore trafficking and activity of delta F508-CFTR ACS Medicinal Chemistry Letters 2011 2:703-707 DOI:10.1021/ml200136e PMID:21984958 PMCID:PMC3187562
- Hutt, D. M., Herman, D., Rodrigues, A. P. C., Noel, S., Pilewski, J. M., Matteson, J., Hoch, B., Kellner, W., Kelly, J. W., Schmidt, A., Thomas, P. J., Matsumura, Y., et al. Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis Nature Chemical Biology 2010 6:25-33 DOI:10.1038/nchembio.275 PMID:19966789 PMCID:PMC2901172
- Xu, C. P., Soragni, E., Chou, C. J., Herman, D., Plasterer, H. L., Rusche, J. R., Gottesfeld, J. M. Chemical probes identify a role for histone deacetylase 3 in Friedreich's ataxia gene silencing Chemistry & Biology 2009 16:980-989 DOI:10.1016/j.chembiol.2009.07.010 PMID:19778726 PMCID:PMC2909763
- Chou, C. J., Herman, D., Gottesfeld, J. M. Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class i histone deacetylases Journal of Biological Chemistry 2008 283:35402-35409 DOI:10.1074/jbc.M807045200 PMID:18953021 PMCID:PMC2602898
- Soragni, E., Herman, D., Dent, S. Y. R., Gottesfeld, J. M., Wells, R. D., Napierala, M. Long intronic GAATTC repeats induce epigenetic changes and reporter gene silencing in a molecular model of Friedreich ataxia Nucleic Acids Research 2008 36:6056-6065 DOI:10.1093/nar/gkn604 PMID:18820300 PMCID:PMC2577344
- Thomas, E. A., Coppola, G., Desplats, P. A., Tang, B., Soragni, E., Burnett, R., Gao, F. Y., Fitzgerald, K. M., Borok, J. F., Herman, D., Geschwind, D. H., Gottesfeld, J. M. The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice Proceedings of the National Academy of Sciences of the United States of America 2008 105:15564-15569 DOI:10.1073/pnas.0804249105 PMID:18829438 PMCID:PMC2563081
- Rai, M., Soragni, E., Jenssen, K., Burnett, R., Herman, D., Coppola, G., Geschwind, D. H., Gottesfeld, J. M., Pandolfo, M. HDAC inhibitors correct frataxin deficiency in a Friedreich ataxia mouse model PLoS One 2008 3:e1958 DOI:10.1371/journal.pone.0001958 PMID:18463734 PMCID:PMC2373517
- Herman, D., Jenssen, K., Burnett, R., Soragni, E., Perlman, S. L., Gottesfeld, J. M. Histone deacetylase inhibitors reverse gene silencing in friedreich's ataxia Nature Chemical Biology 2006 2:551-558 DOI:10.1038/nchembio815 PMID:16921367
- Ehley, J. A., Melander, C., Herman, D., Baird, E. E., Ferguson, H. A., Goodrich, J. A., Dervan, P. B., Gottesfeld, J. M. Promoter scanning for transcription inhibition with DNA-binding polyamides Molecular and Cellular Biology 2002 22:1723-1733 DOI:10.1128/mcb.22.6.1723-1733.2002 PMID:11865052