recent publications

• academic article

  • Hutt, D. M., Olsen, C. A., Vickers, C. J., Herman, D., Chalfant, M. A., Montero, A., Leman, L. J., Burkle, R., Maryanoff, B. E., Balch, W. E., Ghadiri, M. R. Potential agents for treating cystic fibrosis: cyclic tetrapeptides that restore trafficking and activity of delta F508-CFTR ACS Medicinal Chemistry Letters  2011 2:703-707  DOI:10.1021/ml200136e  PMID:21984958  PMCID:PMC3187562
  • Hutt, D. M., Herman, D., Rodrigues, A. P. C., Noel, S., Pilewski, J. M., Matteson, J., Hoch, B., Kellner, W., Kelly, J. W., Schmidt, A., Thomas, P. J., Matsumura, Y., et al. Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis Nature Chemical Biology  2010 6:25-33  DOI:10.1038/nchembio.275  PMID:19966789  PMCID:PMC2901172
  • Xu, C. P., Soragni, E., Chou, C. J., Herman, D., Plasterer, H. L., Rusche, J. R., Gottesfeld, J. M. Chemical probes identify a role for histone deacetylase 3 in Friedreich's ataxia gene silencing Chemistry & Biology  2009 16:980-989  DOI:10.1016/j.chembiol.2009.07.010  PMID:19778726  PMCID:PMC2909763
  • Chou, C. J., Herman, D., Gottesfeld, J. M. Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class i histone deacetylases Journal of Biological Chemistry  2008 283:35402-35409  DOI:10.1074/jbc.M807045200  PMID:18953021  PMCID:PMC2602898
  • Soragni, E., Herman, D., Dent, S. Y. R., Gottesfeld, J. M., Wells, R. D., Napierala, M. Long intronic GAATTC repeats induce epigenetic changes and reporter gene silencing in a molecular model of Friedreich ataxia Nucleic Acids Research  2008 36:6056-6065  DOI:10.1093/nar/gkn604  PMID:18820300  PMCID:PMC2577344
  • Thomas, E. A., Coppola, G., Desplats, P. A., Tang, B., Soragni, E., Burnett, R., Gao, F. Y., Fitzgerald, K. M., Borok, J. F., Herman, D., Geschwind, D. H., Gottesfeld, J. M. The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice Proceedings of the National Academy of Sciences of the United States of America  2008 105:15564-15569  DOI:10.1073/pnas.0804249105  PMID:18829438  PMCID:PMC2563081
  • Rai, M., Soragni, E., Jenssen, K., Burnett, R., Herman, D., Coppola, G., Geschwind, D. H., Gottesfeld, J. M., Pandolfo, M. HDAC inhibitors correct frataxin deficiency in a Friedreich ataxia mouse model PLoS One  2008 3:e1958  DOI:10.1371/journal.pone.0001958  PMID:18463734  PMCID:PMC2373517
  • Herman, D., Jenssen, K., Burnett, R., Soragni, E., Perlman, S. L., Gottesfeld, J. M. Histone deacetylase inhibitors reverse gene silencing in friedreich's ataxia Nature Chemical Biology  2006 2:551-558  DOI:10.1038/nchembio815  PMID:16921367
  • Ehley, J. A., Melander, C., Herman, D., Baird, E. E., Ferguson, H. A., Goodrich, J. A., Dervan, P. B., Gottesfeld, J. M. Promoter scanning for transcription inhibition with DNA-binding polyamides Molecular and Cellular Biology  2002 22:1723-1733  DOI:10.1128/mcb.22.6.1723-1733.2002  PMID:11865052