Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form

Roles for lysophospholipid S1P receptors in multiple sclerosis

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Noguchi, K.
  • Chun, Jerold

publication date

  • February 2011

journal

  • Critical Reviews in Biochemistry and Molecular Biology  Journal

abstract

  • Sphingosine 1-phosphate (S1P) signaling in the treatment of multiple sclerosis (MS) has been highlighted by the efficacy of FTY720 (fingolimod), which upon phosphorylation can modulate S1P receptor activities. FTY720 has become the first oral treatment for relapsing MS that was approved by the FDA in September 2010. Phosphorylated FTY720 modulates four of the five known S1P receptors (S1P(1), S1P(3), S1P(4), and S1P(5)) at high affinity. Studies in human MS and its animal model, experimental autoimmune encephalomyelitis (EAE), have revealed that FTY720 exposure alters lymphocyte trafficking via sequestration of auto-aggressive lymphocytes within lymphoid organs, representing the current understanding of its mechanism of action. These effects primarily involve S1P(1), which is thought to attenuate inflammatory insults in the central nervous system (CNS). In addition, FTY720's actions may involve direct effects on S1P receptor-mediated signaling in CNS cells, based upon the known expression of S1P receptors in CNS cell types relevant to MS, access to the CNS through the blood-brain barrier (BBB), and in vitro studies. These data implicate lysophospholipid signaling--via S1P(1) and perhaps other lysophospholipid receptors--in therapeutic approaches to MS and potentially other diseases with immunological and/or neurological components.

subject areas

  • Animals
  • Central Nervous System
  • Encephalomyelitis, Autoimmune, Experimental
  • Fingolimod Hydrochloride
  • Humans
  • Inflammation
  • Lymphocytes
  • Lysophospholipids
  • Multiple Sclerosis
  • Phosphorylation
  • Propylene Glycols
  • Receptors, Lysophospholipid
  • Signal Transduction
  • Sphingosine
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 1040-9238

Digital Object Identifier (DOI)

  • 10.3109/10409238.2010.522975

PubMed ID

  • 20979571
scroll to property group menus

Additional Document Info

start page

  • 2

end page

  • 10

volume

  • 46

issue

  • 1

©2021 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support