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Regulation of feeding by galnon

Academic Article
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Overview

authors

  • Abramov, U.
  • Floren, A.
  • Echevarria, D. J.
  • Brewer, A.
  • Manuzon, H.
  • Robinson, J. K.
  • Bartfai, Tamas
  • Vasar, E.
  • Langel, Ülo

publication date

  • February 2004

journal

  • Neuropeptides  Journal

abstract

  • Galanin is a neuropeptide that has been implicated in multiple bioactivities, inter alia eating disorders. In this study, we have examined the effects of galnon, a novel low molecular weight galanin receptor ligand. Previous studies have shown that galnon acts as a systemically active, blood-brain barrier crossing agonist on galanin signaling both in vitro and in vivo, inhibiting pentylenetetrazole-induced seizures. Here, intracerebroventricular (10-20 microg) and intraperitoneal (1.5-5 mg/kg) administration of galnon induced a strong, dose-dependent reduction of food intake in rats and mice. This reduction in feeding occurred without reducing general activity and was shown to be attenuated by an intracerebroventricular administration of M35, a peptide galanin antagonist. These data demonstrate that galnon is a promising tool for studies of the involvement of galanin in feeding disorders and other behavioral processes.

subject areas

  • Animals
  • Binding, Competitive
  • Bradykinin
  • Coumarins
  • Dose-Response Relationship, Drug
  • Eating
  • Galanin
  • Injections, Intraperitoneal
  • Injections, Intraventricular
  • Ligands
  • Mice
  • Mice, Inbred C57BL
  • Motor Activity
  • Peptide Fragments
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Galanin
  • Signal Transduction
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Research

keywords

  • GALR
  • M35
  • feeding behavior
  • galanin
  • galnon
  • satiety
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Identity

International Standard Serial Number (ISSN)

  • 0143-4179

Digital Object Identifier (DOI)

  • 10.1016/j.npep.2004.01.001

PubMed ID

  • 15003717
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Additional Document Info

start page

  • 55

end page

  • 61

volume

  • 38

issue

  • 1

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