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Antibody against the leu-cam beta-chain (cd18) promotes both lfa-1-dependent and cr3-dependent adhesion events

Academic Article
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Overview

authors

  • Robinson, M. K.
  • Andrew, D.
  • Rosen, Hugh
  • Brown, D.
  • Ortlepp, S.
  • Stephens, P.
  • Butcher, E. C.

publication date

  • February 1992

journal

  • Journal of Immunology  Journal

abstract

  • The Leukocytic cell-adhesion molecule (beta 2 integrin) family of adhesion molecules play a key role in the intercellular adhesive interactions necessary for normal immune cell function. In this study, we report an antibody that recognizes an epitope on the Leukocytic cell-adhesion molecule common beta-chain (CD18) and promotes both lymphocyte function-associated Ag-1- and CR3-dependent adhesion events. The antibody recognizes a temperature-sensitive epitope that is not dependent on the presence of divalent cations. It is proposed that antibody binding promotes a conformational change in both lymphocyte function-associated Ag-1 and CR3, which may mimic a natural activation mechanism, resulting in increased cellular adhesion.

subject areas

  • Antibodies, Monoclonal
  • Antigens, CD
  • Antigens, CD18
  • Cell Adhesion
  • Cell Aggregation
  • Epitopes
  • Humans
  • Lymphocyte Function-Associated Antigen-1
  • Macrophage-1 Antigen
  • Neutrophils
  • Protein Conformation
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Identity

International Standard Serial Number (ISSN)

  • 0022-1767

PubMed ID

  • 1371129
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Additional Document Info

start page

  • 1080

end page

  • 1085

volume

  • 148

issue

  • 4

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